Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 1936463..1937294 | Replicon | chromosome |
| Accession | NZ_CP069677 | ||
| Organism | Escherichia coli O126:H45 strain MIN10 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | S1P968 |
| Locus tag | JSU12_RS09260 | Protein ID | WP_000854814.1 |
| Coordinates | 1936463..1936837 (-) | Length | 125 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | B3Y195 |
| Locus tag | JSU12_RS09265 | Protein ID | WP_001285585.1 |
| Coordinates | 1936926..1937294 (-) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JSU12_RS09220 (1931859) | 1931859..1933025 | + | 1167 | WP_000830150.1 | serine-type D-Ala-D-Ala carboxypeptidase DacD | - |
| JSU12_RS09225 (1933144) | 1933144..1933617 | + | 474 | WP_001105389.1 | DNA gyrase inhibitor SbmC | - |
| JSU12_RS09230 (1933815) | 1933815..1934873 | + | 1059 | WP_001200891.1 | FUSC family protein | - |
| JSU12_RS09235 (1935045) | 1935045..1935374 | + | 330 | WP_000450409.1 | DUF496 family protein | - |
| JSU12_RS09240 (1935475) | 1935475..1935609 | - | 135 | WP_001297944.1 | EutP/PduV family microcompartment system protein | - |
| JSU12_RS09245 (1935729) | 1935729..1935857 | + | 129 | Protein_1817 | transposase domain-containing protein | - |
| JSU12_RS09250 (1936146) | 1936146..1936226 | - | 81 | Protein_1818 | hypothetical protein | - |
| JSU12_RS09255 (1936272) | 1936272..1936466 | - | 195 | WP_000988600.1 | DUF5983 family protein | - |
| JSU12_RS09260 (1936463) | 1936463..1936837 | - | 375 | WP_000854814.1 | type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA | Toxin |
| JSU12_RS09265 (1936926) | 1936926..1937294 | - | 369 | WP_001285585.1 | type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA | Antitoxin |
| JSU12_RS09270 (1937368) | 1937368..1937589 | - | 222 | WP_000692323.1 | DUF987 domain-containing protein | - |
| JSU12_RS09275 (1937652) | 1937652..1938128 | - | 477 | WP_001186726.1 | RadC family protein | - |
| JSU12_RS09280 (1938144) | 1938144..1938623 | - | 480 | WP_000860087.1 | antirestriction protein | - |
| JSU12_RS09285 (1938705) | 1938705..1939523 | - | 819 | WP_054472832.1 | DUF932 domain-containing protein | - |
| JSU12_RS09290 (1939623) | 1939623..1939856 | - | 234 | WP_001119729.1 | DUF905 family protein | - |
| JSU12_RS09295 (1939935) | 1939935..1940389 | - | 455 | Protein_1827 | IrmA family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 125 a.a. Molecular weight: 13898.94 Da Isoelectric Point: 7.8522
>T191583 WP_000854814.1 NZ_CP069677:c1936837-1936463 [Escherichia coli O126:H45]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK
Download Length: 375 bp
>T191583 NZ_CP091833:3301809-3302210 [Shewanella xiamenensis]
TTGAATGACATTATTATCAATAAAATAGCCACCATCAAACGCTGTATAAAGCGCATCCAACAAGTCTATGGTGATGGAAG
CCAGTTCAAACAAGACTTCACCTTGCAAGATAGCGTTATCCTCAATTTACAACGCTGCTGCGAAGCCTGTATCGACATAG
CCAATCATATTAACCGCCAACAACAACTAGGCATCCCCCAAAGTAGCCGTGATAGCTTTACATTACTCGCACAAAATAAC
CTTATTACTCAGCCACTCGCAGATAACTTAAAGAAAATGGTCGGCCTGCGAAACATCGCAGTACATGACTACCAAGAACT
CAACCTTGATATCGTTGTCCATGTTGTACAGCATCATCTTGAGGATTTTGAGCAATTTATTGATGTGATAAAAGCAGAGT
GA
TTGAATGACATTATTATCAATAAAATAGCCACCATCAAACGCTGTATAAAGCGCATCCAACAAGTCTATGGTGATGGAAG
CCAGTTCAAACAAGACTTCACCTTGCAAGATAGCGTTATCCTCAATTTACAACGCTGCTGCGAAGCCTGTATCGACATAG
CCAATCATATTAACCGCCAACAACAACTAGGCATCCCCCAAAGTAGCCGTGATAGCTTTACATTACTCGCACAAAATAAC
CTTATTACTCAGCCACTCGCAGATAACTTAAAGAAAATGGTCGGCCTGCGAAACATCGCAGTACATGACTACCAAGAACT
CAACCTTGATATCGTTGTCCATGTTGTACAGCATCATCTTGAGGATTTTGAGCAATTTATTGATGTGATAAAAGCAGAGT
GA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13593.48 Da Isoelectric Point: 6.3139
>AT191583 WP_001285585.1 NZ_CP069677:c1937294-1936926 [Escherichia coli O126:H45]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN
Download Length: 369 bp
>AT191583 NZ_CP091833:3301394-3301816 [Shewanella xiamenensis]
ATGCAACAACTAAATGAAAAGAAAATCATAAAGTTACTGCGAGACAACATCCCAAAGTTGCAATTAATCTACCTGTTTGG
CTCTTATTCGCAGGGAACACAACACCGCAACAGCGATATCGATATCGCGGTACTCGCCGCTGACACTTTAGACAATATTG
CACGCTGGGAACTTGCCCAAAAACTCGCTTCGGCGTTGGACTCAGATGTTGATCTGGTTGATTTACGCTCAGCATCCACA
GTGTTATGCCAACAGGTAGTCACTCAAGGGAAGCAACTTTGGGGAACACAACAAGATGATGAACTTTTTGCCGTAAAGAC
CATCTCAATGTACCAACATCTACAAGCCGAAAGACAGGCAATTATTGATGATGTAATGGCCAACACCGCAGCCAAAGATC
ATAGGGGGAGTCACTTTGAATGA
ATGCAACAACTAAATGAAAAGAAAATCATAAAGTTACTGCGAGACAACATCCCAAAGTTGCAATTAATCTACCTGTTTGG
CTCTTATTCGCAGGGAACACAACACCGCAACAGCGATATCGATATCGCGGTACTCGCCGCTGACACTTTAGACAATATTG
CACGCTGGGAACTTGCCCAAAAACTCGCTTCGGCGTTGGACTCAGATGTTGATCTGGTTGATTTACGCTCAGCATCCACA
GTGTTATGCCAACAGGTAGTCACTCAAGGGAAGCAACTTTGGGGAACACAACAAGATGATGAACTTTTTGCCGTAAAGAC
CATCTCAATGTACCAACATCTACAAGCCGAAAGACAGGCAATTATTGATGATGTAATGGCCAACACCGCAGCCAAAGATC
ATAGGGGGAGTCACTTTGAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A829FY50 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U9LW60 |