Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1432654..1433279 Replicon chromosome
Accession NZ_CP069677
Organism Escherichia coli O126:H45 strain MIN10

Toxin (Protein)


Gene name vapC Uniprot ID U9YZ02
Locus tag JSU12_RS06980 Protein ID WP_000911329.1
Coordinates 1432881..1433279 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag JSU12_RS06975 Protein ID WP_000450524.1
Coordinates 1432654..1432881 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JSU12_RS06950 (1428456) 1428456..1428926 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
JSU12_RS06955 (1428926) 1428926..1429498 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
JSU12_RS06960 (1429644) 1429644..1430522 + 879 WP_001311023.1 4-hydroxy-tetrahydrodipicolinate synthase -
JSU12_RS06965 (1430539) 1430539..1431573 + 1035 WP_023142816.1 outer membrane protein assembly factor BamC -
JSU12_RS06970 (1431786) 1431786..1432499 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
JSU12_RS06975 (1432654) 1432654..1432881 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
JSU12_RS06980 (1432881) 1432881..1433279 + 399 WP_000911329.1 type II toxin-antitoxin system VapC family toxin Toxin
JSU12_RS06985 (1433426) 1433426..1434289 + 864 WP_001267498.1 neutral zinc metallopeptidase -
JSU12_RS06990 (1434304) 1434304..1436319 + 2016 WP_000829294.1 tRNA cytosine(34) acetyltransferase TmcA -
JSU12_RS06995 (1436393) 1436393..1437091 + 699 WP_000679823.1 esterase -
JSU12_RS07000 (1437201) 1437201..1437401 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14924.23 Da        Isoelectric Point: 8.5325

>T191581 WP_000911329.1 NZ_CP069677:1432881-1433279 [Escherichia coli O126:H45]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLEVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

>T191581 NZ_CP091833:703086-704387 [Shewanella xiamenensis]
ATGAGTACAGCTAAAACGCTTACGCTAGAGATGCACCTCGGTGATTTAATGATCGGGGAATTATCCTTTGATGCCACGAC
CGACACCTTTGCGGTGTATTACACCAAAGATTGGCAGCAAAGTGGGTTTCCACTATCCCCAACGATTCCTTTAGATTGCA
CAGGAACGAGCAATCAAATATCAATGTTTTTGGTCAACTTATTACCAGAAAACAAAGGATTAGATTATCTGATTGAATCG
CTTGGCGTCTCTAAGGGGAATACCTTTGCCTTGATCCGCGCCATTGGTCTCGATACCGCAGGTGCCATCGCTTTCGTTCC
TAAAGGGGCTTTACTGCCTGAAACACAATTGCGGCCAATTAAGGCTGCAGAAGTTATTCAACGCATTGAAGATCCCACAA
TGTGGCCGATGGAAATTTGGGACGGCAAACCTCGACTATCGGTAGCGGGTGTTCAACCTAAATTAAACCTGTTTTATAAC
GGGAAAGAATTTGCCTTTGCCGAAGGTACGCTGTCATCGACCCACATAGTTAAATTCGAAAAATATCATCATTTAGTGAT
CAATGAATTTATAACGATGCGTTTGGCCAAAGTGATTGGAATGAATGTGGCGAATGTCGATATTGTTCATTTTGGCAGTT
ACAAAGCCCTTTGTGTTGAACGCTTTGACAGACGTTATATACCAAGCGAGCAAAGGGTGTTAAGAAGGCATATTGTCGAT
AGCTGCCAAGCACTTGGTTTTAGTGTAAGCAAAAAATATGAACGTAATTTCGGTACGGGGCGCGATGTTAAAGATATTCG
TGAAGGGGTAAGTTTTAAGAGGCTATTTAGTCTTGCTGAAAAATGCCGTAATCCCGTGGCTGCTAAGCAAGACATATTGC
AATGGACGCTATTCAATTTACTGACCGGTAATGCCGATGCACACGGTAAAAACTACTCATTTTTTATGACGCCAAGCGGA
ATGGAGCCAACGCCTTGGTACGATTTGGTCAGCGTGGCTATGTATGAGGATTTTGAACAACAGCTTGCGATGGCAATTGA
TGACGAATTTGATCCAAATAGCATTTACGCCTATCAATTAGCCGCGTTTATGGATGGCTTGGGTTTACCAAGAAATTTAT
TAGTCAGTAACTTAACGAGAATAGCGCGGAGAATACCGCAGGCAATAGCGGAGGTGATTTTAATGCTCCCGCCCCTTGAT
GAAGATGAAGCATCATTTGTGGCTCATTACAAAGCGCAGTTACTGGCGAGATGTGAACGTTACCTTAGTTTTGCTGACGA
GGTCAGGGATGTGGAAGTGTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT191581 WP_000450524.1 NZ_CP069677:1432654-1432881 [Escherichia coli O126:H45]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp

>AT191581 NZ_CP091833:702846-703082 [Shewanella xiamenensis]
ATGGCATCACCGCTAAATCAGCAATCCCTCGGCTTGTTAATTAAAGAACGCAGGAAAAGTGCTGCTCTTACCCAAGACGT
GGCGGCCATGCTGTGCGGCGTAACCAAAAAAACGCTGATCCGAGTTGAAAAGGGTGAGGATGTTTATATCTCAACCGTAT
TCAAAATCCTTGATGGTCTTGGGATTGATATCGTTTCGGCTCAAACCAGCAATACCGAAACTAACGGCTGGTATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XW84

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References