Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4266005..4266800 Replicon chromosome
Accession NZ_CP069666
Organism Escherichia coli O89m:H9 strain MIN11

Toxin (Protein)


Gene name yeeV Uniprot ID A0A658LKE6
Locus tag JSU13_RS20480 Protein ID WP_001596171.1
Coordinates 4266426..4266800 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A6D0GHH4
Locus tag JSU13_RS20475 Protein ID WP_071342845.1
Coordinates 4266005..4266379 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JSU13_RS20445 (4261360) 4261360..4262265 + 906 WP_000203530.1 diguanylate cyclase regulator RdcB family protein -
JSU13_RS20450 (4262262) 4262262..4263332 + 1071 WP_021564623.1 patatin-like phospholipase family protein -
JSU13_RS20455 (4263672) 4263672..4264490 + 819 WP_073991181.1 DUF932 domain-containing protein -
JSU13_RS20460 (4264582) 4264582..4265067 + 486 WP_073991182.1 antirestriction protein -
JSU13_RS20465 (4265082) 4265082..4265558 + 477 WP_001186726.1 RadC family protein -
JSU13_RS20470 (4265621) 4265621..4265842 + 222 WP_000692323.1 DUF987 domain-containing protein -
JSU13_RS20475 (4266005) 4266005..4266379 + 375 WP_071342845.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JSU13_RS20480 (4266426) 4266426..4266800 + 375 WP_001596171.1 TA system toxin CbtA family protein Toxin
JSU13_RS20485 (4266797) 4266797..4267288 + 492 WP_123000901.1 DUF5983 family protein -
JSU13_RS20490 (4267300) 4267300..4267497 + 198 WP_001596173.1 DUF957 domain-containing protein -
JSU13_RS20495 (4267582) 4267582..4268424 + 843 WP_042093078.1 DUF4942 domain-containing protein -
JSU13_RS20500 (4269173) 4269173..4270711 + 1539 WP_001187173.1 lysine decarboxylation/transport transcriptional activator CadC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14161.14 Da        Isoelectric Point: 6.7041

>T191569 WP_001596171.1 NZ_CP069666:4266426-4266800 [Escherichia coli O89m:H9]
MKTLPDTHVREASRCPSPVTIWQTLLARLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYELVRTDQPEF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T191569 NZ_CP091813:329524-329892 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13744.51 Da        Isoelectric Point: 6.4757

>AT191569 WP_071342845.1 NZ_CP069666:4266005-4266379 [Escherichia coli O89m:H9]
VSDTLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLTVYPTPAPATTS

Download         Length: 375 bp

>AT191569 NZ_CP091813:329306-329527 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A658LKE6

Antitoxin

Source ID Structure
AlphaFold DB A0A6D0GHH4

References