Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 3522379..3523213 | Replicon | chromosome |
| Accession | NZ_CP069666 | ||
| Organism | Escherichia coli O89m:H9 strain MIN11 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A2X7CAN1 |
| Locus tag | JSU13_RS16890 | Protein ID | WP_039025883.1 |
| Coordinates | 3522379..3522756 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | - |
| Locus tag | JSU13_RS16895 | Protein ID | WP_001285578.1 |
| Coordinates | 3522845..3523213 (-) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JSU13_RS16860 (3517637) | 3517637..3518593 | + | 957 | WP_000121359.1 | molybdenum cofactor insertion chaperone PaoD | - |
| JSU13_RS16865 (3518644) | 3518644..3518982 | + | 339 | Protein_3338 | LysR substrate-binding domain-containing protein | - |
| JSU13_RS16870 (3519320) | 3519320..3520639 | + | 1320 | WP_000144688.1 | site-specific integrase | - |
| JSU13_RS16875 (3520732) | 3520732..3521580 | - | 849 | WP_039025884.1 | DUF4942 domain-containing protein | - |
| JSU13_RS16880 (3521677) | 3521677..3521874 | - | 198 | WP_000772024.1 | DUF957 domain-containing protein | - |
| JSU13_RS16885 (3521894) | 3521894..3522382 | - | 489 | Protein_3342 | DUF5983 family protein | - |
| JSU13_RS16890 (3522379) | 3522379..3522756 | - | 378 | WP_039025883.1 | type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA | Toxin |
| JSU13_RS16895 (3522845) | 3522845..3523213 | - | 369 | WP_001285578.1 | type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA | Antitoxin |
| JSU13_RS16900 (3523293) | 3523293..3523514 | - | 222 | WP_000692326.1 | DUF987 domain-containing protein | - |
| JSU13_RS16905 (3523577) | 3523577..3524053 | - | 477 | WP_001186725.1 | RadC family protein | - |
| JSU13_RS16910 (3524069) | 3524069..3524515 | - | 447 | WP_208207783.1 | antirestriction protein | - |
| JSU13_RS16915 (3524556) | 3524556..3524783 | - | 228 | WP_208207743.1 | hypothetical protein | - |
| JSU13_RS16920 (3524780) | 3524780..3525622 | - | 843 | WP_208207744.1 | DUF932 domain-containing protein | - |
| JSU13_RS16925 (3525967) | 3525967..3526425 | + | 459 | WP_208207745.1 | IS200/IS605 family transposase | - |
| JSU13_RS24550 (3526534) | 3526534..3526656 | - | 123 | WP_264118768.1 | hypothetical protein | - |
| JSU13_RS16930 (3526735) | 3526735..3527577 | - | 843 | WP_251361216.1 | hypothetical protein | - |
| JSU13_RS16935 (3527751) | 3527751..3528161 | - | 411 | WP_208207747.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 3525967..3526425 | 458 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14176.22 Da Isoelectric Point: 7.8523
>T191565 WP_039025883.1 NZ_CP069666:c3522756-3522379 [Escherichia coli O89m:H9]
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQLEF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYQEAKR
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQLEF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYQEAKR
Download Length: 378 bp
>T191565 NZ_CP091805:c4738089-4737808 [Klebsiella quasipneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGCTTGGCGAGACGGTCAAAAAACAGTTCAAAAA
TAATCTCCAGCAGATTATGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTGCCGGATTGCTACAAAATCAAGC
TTAAGGCGTCAGGTTATCGGCTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAAAGA
GAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGCTTGGCGAGACGGTCAAAAAACAGTTCAAAAA
TAATCTCCAGCAGATTATGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTGCCGGATTGCTACAAAATCAAGC
TTAAGGCGTCAGGTTATCGGCTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAAAGA
GAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13607.39 Da Isoelectric Point: 6.3147
>AT191565 WP_001285578.1 NZ_CP069666:c3523213-3522845 [Escherichia coli O89m:H9]
VSDTLPGTTHPDNNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN
VSDTLPGTTHPDNNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN
Download Length: 369 bp
>AT191565 NZ_CP091805:c4738321-4738079 [Klebsiella quasipneumoniae]
ATGGCCACGCTCAACGTTCGACTGGATGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACGCC
AACGGAGGCGGTACGTCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGCGATG
GCGAAGCGGCGTTGTTACGCACCGTTCGCGAGCGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA
ATGGCCACGCTCAACGTTCGACTGGATGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACGCC
AACGGAGGCGGTACGTCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGCGATG
GCGAAGCGGCGTTGTTACGCACCGTTCGCGAGCGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|