Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3883747..3884579 Replicon chromosome
Accession NZ_CP069646
Organism Escherichia coli O7:H4 strain MIN14

Toxin (Protein)


Gene name yeeV Uniprot ID A0A3P5UBZ5
Locus tag JSU15_RS18830 Protein ID WP_001094454.1
Coordinates 3883747..3884121 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A3G8RJV8
Locus tag JSU15_RS18835 Protein ID WP_001320394.1
Coordinates 3884211..3884579 (-) Length 123 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JSU15_RS18800 (3878860) 3878860..3880008 - 1149 WP_000905931.1 capsule polysaccharide export inner-membrane protein KpsE -
JSU15_RS18805 (3880080) 3880080..3881063 - 984 WP_024181915.1 KpsF/GutQ family sugar-phosphate isomerase -
JSU15_RS18810 (3881874) 3881874..3882044 - 171 Protein_3722 IS110 family transposase -
JSU15_RS18815 (3882387) 3882387..3882956 - 570 WP_208231899.1 DUF4942 domain-containing protein -
JSU15_RS18820 (3883053) 3883053..3883250 - 198 WP_000839276.1 DUF957 domain-containing protein -
JSU15_RS18825 (3883262) 3883262..3883750 - 489 WP_000777545.1 DUF5983 family protein -
JSU15_RS18830 (3883747) 3883747..3884121 - 375 WP_001094454.1 TA system toxin CbtA family protein Toxin
JSU15_RS18835 (3884211) 3884211..3884579 - 369 WP_001320394.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JSU15_RS18840 (3884629) 3884629..3885272 - 644 Protein_3728 antitoxin of toxin-antitoxin stability system -
JSU15_RS18845 (3885291) 3885291..3885512 - 222 WP_000692300.1 DUF987 domain-containing protein -
JSU15_RS18850 (3885575) 3885575..3886051 - 477 WP_001347688.1 RadC family protein -
JSU15_RS18855 (3886067) 3886067..3886552 - 486 WP_029701480.1 antirestriction protein -
JSU15_RS18860 (3886607) 3886607..3887425 - 819 WP_001234642.1 DUF932 domain-containing protein -
JSU15_RS18865 (3887525) 3887525..3887758 - 234 WP_001119719.1 DUF905 family protein -
JSU15_RS18870 (3887837) 3887837..3888292 - 456 WP_000581493.1 IrmA family protein -
JSU15_RS18875 (3888369) 3888369..3889367 - 999 Protein_3735 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-112)

Antitoxin

(18-117)


Sequences


Toxin        


Download         Length: 125 a.a.        Molecular weight: 14059.10 Da        Isoelectric Point: 9.2447

>T191512 WP_001094454.1 NZ_CP069646:c3884121-3883747 [Escherichia coli O7:H4]
MNTLPDTHVRKASRCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEKR

Download         Length: 375 bp

>T191512 NZ_CP091757:53927-54409 [Escherichia coli]
GTGGGACGTATAACCACGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGTAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGGGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13623.22 Da        Isoelectric Point: 6.4783

>AT191512 WP_001320394.1 NZ_CP069646:c3884579-3884211 [Escherichia coli O7:H4]
VSDTFSGTTHPDDNHDRPWWGLPSTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADANHLDQAFPLLMKQLELMFTSS
ELNPHRQNTVTLYAKGLTCHADTLGSCGYVYLAVYPTPETKQ

Download         Length: 369 bp

>AT191512 NZ_CP091757:53673-53939 [Escherichia coli]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCTGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A3P5UBZ5


Antitoxin

Source ID Structure
AlphaFold DB A0A3G8RJV8

References