Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PanAT/DUF4065(antitoxin) |
| Location | 2650604..2651648 | Replicon | chromosome |
| Accession | NZ_CP069646 | ||
| Organism | Escherichia coli O7:H4 strain MIN14 | ||
Toxin (Protein)
| Gene name | panT | Uniprot ID | A0A839B4R0 |
| Locus tag | JSU15_RS13035 | Protein ID | WP_000019187.1 |
| Coordinates | 2650604..2651152 (-) | Length | 183 a.a. |
Antitoxin (Protein)
| Gene name | panA | Uniprot ID | A0A839B6W4 |
| Locus tag | JSU15_RS13040 | Protein ID | WP_000287252.1 |
| Coordinates | 2651175..2651648 (-) | Length | 158 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JSU15_RS13000 (2645896) | 2645896..2646720 | + | 825 | WP_000081287.1 | DUF2303 family protein | - |
| JSU15_RS13005 (2646848) | 2646848..2647384 | + | 537 | WP_000008174.1 | 5'-deoxynucleotidase | - |
| JSU15_RS13010 (2647375) | 2647375..2647736 | + | 362 | Protein_2588 | hypothetical protein | - |
| JSU15_RS24810 (2648117) | 2648117..2648356 | + | 240 | Protein_2589 | DUF551 domain-containing protein | - |
| JSU15_RS13020 (2648356) | 2648356..2648928 | + | 573 | WP_001061350.1 | 3'-5' exonuclease | - |
| JSU15_RS13025 (2648965) | 2648965..2649249 | + | 285 | WP_208231827.1 | pyocin activator PrtN family protein | - |
| JSU15_RS13030 (2649272) | 2649272..2650480 | - | 1209 | WP_000343728.1 | IS256-like element IS1414 family transposase | - |
| JSU15_RS13035 (2650604) | 2650604..2651152 | - | 549 | WP_000019187.1 | hypothetical protein | Toxin |
| JSU15_RS13040 (2651175) | 2651175..2651648 | - | 474 | WP_000287252.1 | DUF4065 domain-containing protein | Antitoxin |
| JSU15_RS13045 (2651953) | 2651953..2652057 | - | 105 | Protein_2595 | tRNA-dihydrouridine synthase | - |
| JSU15_RS13050 (2652420) | 2652420..2653166 | - | 747 | WP_001319310.1 | DUF2713 family protein | - |
| JSU15_RS25080 (2653157) | 2653157..2653441 | - | 285 | WP_001329185.1 | hypothetical protein | - |
| JSU15_RS13055 (2653760) | 2653760..2654275 | + | 516 | WP_001295691.1 | zinc uptake transcriptional repressor Zur | - |
| JSU15_RS13060 (2654317) | 2654317..2654526 | - | 210 | WP_001030593.1 | CsbD family protein | - |
| JSU15_RS13065 (2654642) | 2654642..2655967 | - | 1326 | WP_001301116.1 | MATE family efflux transporter DinF | - |
| JSU15_RS13070 (2656040) | 2656040..2656648 | - | 609 | WP_000646078.1 | transcriptional repressor LexA | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2611460..2656648 | 45188 | |
| - | flank | IS/Tn | - | - | 2649272..2650480 | 1208 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 183 a.a. Molecular weight: 19966.42 Da Isoelectric Point: 4.5662
>T191509 WP_000019187.1 NZ_CP069646:c2651152-2650604 [Escherichia coli O7:H4]
MSHNSDIYKLIGAAAGVENGRSEASLNSTDSQEQIFKSAFEPSNHESDDDSSSENKAILEAEEFGSNTGALHEFMQQNRM
DSLQAQLDMLKSQVRDKIADATGKEIDNELRTKMASFTVWFMSCWCLFVVAMFTSFLIAHEGKPPVEAIVALLGTSTISI
VGLVGFVVSGLFKSRKDSDKEK
MSHNSDIYKLIGAAAGVENGRSEASLNSTDSQEQIFKSAFEPSNHESDDDSSSENKAILEAEEFGSNTGALHEFMQQNRM
DSLQAQLDMLKSQVRDKIADATGKEIDNELRTKMASFTVWFMSCWCLFVVAMFTSFLIAHEGKPPVEAIVALLGTSTISI
VGLVGFVVSGLFKSRKDSDKEK
Download Length: 549 bp
>T191509 NZ_CP091756:3895636-3895914 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA
Antitoxin
Download Length: 158 a.a. Molecular weight: 17298.80 Da Isoelectric Point: 8.4143
>AT191509 WP_000287252.1 NZ_CP069646:c2651648-2651175 [Escherichia coli O7:H4]
MYSPVQIANKFITLGNQHHNPLTHMQLQKLTYIAHGYYLALTGKPLLNECVSAWKYGPVIPGMYDAFKDYGNKPVTNVAV
APFGGIVTMDPQAESIIGAVYKFYGSKNGIELSTLTHMPGTPWSQAYNGIGSSIISNDAIKAYYHDLLNNRQQCQGL
MYSPVQIANKFITLGNQHHNPLTHMQLQKLTYIAHGYYLALTGKPLLNECVSAWKYGPVIPGMYDAFKDYGNKPVTNVAV
APFGGIVTMDPQAESIIGAVYKFYGSKNGIELSTLTHMPGTPWSQAYNGIGSSIISNDAIKAYYHDLLNNRQQCQGL
Download Length: 474 bp
>AT191509 NZ_CP091756:3895373-3895633 [Escherichia coli]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCAGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCATTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCAGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCATTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A839B4R0 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A839B6W4 |