Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2508229..2509064 Replicon chromosome
Accession NZ_CP069646
Organism Escherichia coli O7:H4 strain MIN14

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag JSU15_RS12295 Protein ID WP_001565141.1
Coordinates 2508687..2509064 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag JSU15_RS12290 Protein ID WP_001565140.1
Coordinates 2508229..2508597 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JSU15_RS12270 (2505977) 2505977..2506795 + 819 WP_021536653.1 DUF932 domain-containing protein -
JSU15_RS12275 (2506887) 2506887..2507372 + 486 WP_001565139.1 antirestriction protein -
JSU15_RS12280 (2507388) 2507388..2507864 + 477 WP_001186725.1 RadC family protein -
JSU15_RS12285 (2507933) 2507933..2508154 + 222 WP_000692303.1 DUF987 domain-containing protein -
JSU15_RS12290 (2508229) 2508229..2508597 + 369 WP_001565140.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JSU15_RS12295 (2508687) 2508687..2509064 + 378 WP_001565141.1 TA system toxin CbtA family protein Toxin
JSU15_RS12300 (2509061) 2509061..2509549 + 489 WP_021536652.1 DUF5983 family protein -
JSU15_RS12305 (2509561) 2509561..2509758 + 198 WP_021536651.1 DUF957 domain-containing protein -
JSU15_RS12310 (2509843) 2509843..2510685 + 843 WP_021536650.1 DUF4942 domain-containing protein -
JSU15_RS12315 (2511435) 2511435..2512973 + 1539 WP_001187177.1 lysine decarboxylation/transport transcriptional activator CadC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - papC 2465892..2520786 54894


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14246.27 Da        Isoelectric Point: 7.2920

>T191507 WP_001565141.1 NZ_CP069646:2508687-2509064 [Escherichia coli O7:H4]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SICPRSQLINSIDILRARRATGLMTRDNYRMVNNITQGKHPEAQQ

Download         Length: 378 bp

>T191507 NZ_CP091756:3655506-3655724 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13604.41 Da        Isoelectric Point: 6.7389

>AT191507 WP_001565140.1 NZ_CP069646:2508229-2508597 [Escherichia coli O7:H4]
VSDTLPGTTHPDDNHDRLWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSNADAYHLDQAFALLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT191507 NZ_CP091756:3655106-3655480 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References