191506

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 2274922..2275736 Replicon chromosome
Accession NZ_CP069646
Organism Escherichia coli O7:H4 strain MIN14

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag JSU15_RS11135 Protein ID WP_001054376.1
Coordinates 2274922..2275179 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag JSU15_RS11140 Protein ID WP_001309181.1
Coordinates 2275191..2275736 (+) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JSU15_RS11115 (2270210) 2270210..2271316 + 1107 WP_001309184.1 N-acetylneuraminate epimerase -
JSU15_RS11120 (2271381) 2271381..2272361 + 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
JSU15_RS24770 (2272471) 2272471..2272676 + 206 Protein_2208 HNH endonuclease -
JSU15_RS11125 (2272944) 2272944..2274184 - 1241 Protein_2209 helicase YjhR -
JSU15_RS24775 (2274300) 2274300..2274431 + 132 WP_001309182.1 hypothetical protein -
JSU15_RS11135 (2274922) 2274922..2275179 + 258 WP_001054376.1 YjhX family toxin Toxin
JSU15_RS11140 (2275191) 2275191..2275736 + 546 WP_001309181.1 N-acetyltransferase Antitoxin
JSU15_RS11145 (2275792) 2275792..2276538 + 747 WP_000354251.1 class I SAM-dependent methyltransferase -
JSU15_RS11150 (2276707) 2276707..2276925 + 219 Protein_2214 hypothetical protein -
JSU15_RS11155 (2276963) 2276963..2277079 + 117 Protein_2215 VOC family protein -
JSU15_RS11160 (2277324) 2277324..2278445 + 1122 WP_000010829.1 M42 family metallopeptidase -
JSU15_RS11165 (2278442) 2278442..2278720 + 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
JSU15_RS11170 (2278732) 2278732..2280045 + 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T191506 WP_001054376.1 NZ_CP069646:2274922-2275179 [Escherichia coli O7:H4]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

>T191506 NZ_CP091756:2859774-2859881 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT191506 WP_001309181.1 NZ_CP069646:2275191-2275736 [Escherichia coli O7:H4]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT191506 NZ_CP091756:c2859727-2859661 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References