191502

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1717315..1717933 Replicon chromosome
Accession NZ_CP069646
Organism Escherichia coli O7:H4 strain MIN14

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag JSU15_RS08495 Protein ID WP_001291435.1
Coordinates 1717715..1717933 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag JSU15_RS08490 Protein ID WP_000344800.1
Coordinates 1717315..1717689 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JSU15_RS08480 (1712404) 1712404..1713597 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
JSU15_RS08485 (1713620) 1713620..1716769 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
JSU15_RS08490 (1717315) 1717315..1717689 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
JSU15_RS08495 (1717715) 1717715..1717933 + 219 WP_001291435.1 HHA domain-containing protein Toxin
JSU15_RS08500 (1718105) 1718105..1718656 + 552 WP_000102564.1 maltose O-acetyltransferase -
JSU15_RS08505 (1718772) 1718772..1719242 + 471 WP_000136192.1 YlaC family protein -
JSU15_RS08510 (1719406) 1719406..1720956 + 1551 WP_001319841.1 cyclic-guanylate-specific phosphodiesterase PdeB -
JSU15_RS08515 (1720998) 1720998..1721351 - 354 WP_000878140.1 DUF1428 domain-containing protein -
JSU15_RS08525 (1721730) 1721730..1722041 + 312 WP_000409911.1 MGMT family protein -
JSU15_RS08530 (1722072) 1722072..1722644 - 573 WP_000779826.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T191502 WP_001291435.1 NZ_CP069646:1717715-1717933 [Escherichia coli O7:H4]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T191502 NZ_CP091756:2147663-2147766 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT191502 WP_000344800.1 NZ_CP069646:1717315-1717689 [Escherichia coli O7:H4]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT191502 NZ_CP091756:c2147804-2147533 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References