Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1559..2075 Replicon plasmid pMUT2
Accession NZ_CP069625
Organism Escherichia coli strain PBP8

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag JSQ93_RS24185 Protein ID WP_001554709.1
Coordinates 1791..2075 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A8H9DQ25
Locus tag JSQ93_RS24180 Protein ID WP_001554710.1
Coordinates 1559..1801 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JSQ93_RS24170 (JSQ93_23930) 1..5514 - 5514 WP_024199421.1 anti-phage protein KwaA -
JSQ93_RS24175 (JSQ93_23935) 398..1294 - 897 WP_024199422.1 replication initiation protein -
JSQ93_RS24180 (JSQ93_23940) 1559..1801 + 243 WP_001554710.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
JSQ93_RS24185 (JSQ93_23945) 1791..2075 + 285 WP_001554709.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JSQ93_RS24190 (JSQ93_23950) 2120..2344 - 225 WP_223938297.1 MbeD family mobilization/exclusion protein -
JSQ93_RS24195 2955..3419 - 465 Protein_5 relaxase/mobilization nuclease domain-containing protein -
JSQ93_RS24200 (JSQ93_23960) 3577..3903 - 327 WP_001554615.1 MobC family plasmid mobilization relaxosome protein -
JSQ93_RS24205 (JSQ93_23965) 4130..5272 - 1143 WP_001704287.1 DUF4868 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..5514 5514


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-77)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11265.07 Da        Isoelectric Point: 10.4971

>T191329 WP_001554709.1 NZ_CP069625:1791-2075 [Escherichia coli]
MSYNLEFDPRALKEWRKLGDDVRLQFKKKLEQVLQHPRIDKNRLRELHDCYKIKLRASGYRLVYQVRDQTITVFVVAVGK
RERSAAYDAADKRL

Download         Length: 285 bp

>T191329 NZ_CP091677:c4259422-4259315 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8958.21 Da        Isoelectric Point: 4.2821

>AT191329 WP_001554710.1 NZ_CP069625:1559-1801 [Escherichia coli]
MATINIRIDDELKSRSYAALEKLGVTPSEVLRQTLEYVAQSGRLPFQQVLLTEDDADLMAIVRDRLENPQAGVKVSLDEL

Download         Length: 243 bp

>AT191329 NZ_CP091677:4259479-4259536 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References