Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 1801753..1802587 | Replicon | chromosome |
| Accession | NZ_CP069624 | ||
| Organism | Escherichia coli strain PBP8 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | S1PLF5 |
| Locus tag | JSQ93_RS08495 | Protein ID | WP_000854690.1 |
| Coordinates | 1802210..1802587 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | - |
| Locus tag | JSQ93_RS08490 | Protein ID | WP_119023792.1 |
| Coordinates | 1801753..1802121 (+) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JSQ93_RS08450 (1796835) | 1796835..1797962 | + | 1128 | Protein_1657 | hypothetical protein | - |
| JSQ93_RS08455 (1798038) | 1798038..1798493 | + | 456 | WP_000581502.1 | IrmA family protein | - |
| JSQ93_RS08460 (1798572) | 1798572..1798805 | + | 234 | WP_000902034.1 | DUF905 family protein | - |
| JSQ93_RS08465 (1798906) | 1798906..1799724 | + | 819 | WP_001234620.1 | DUF932 domain-containing protein | - |
| JSQ93_RS08470 (1799779) | 1799779..1800264 | + | 486 | WP_000849565.1 | antirestriction protein | - |
| JSQ93_RS08475 (1800280) | 1800280..1800756 | + | 477 | WP_001186726.1 | RadC family protein | - |
| JSQ93_RS08480 (1800819) | 1800819..1801040 | + | 222 | WP_000692329.1 | DUF987 domain-containing protein | - |
| JSQ93_RS08485 (1801059) | 1801059..1801703 | + | 645 | WP_000094916.1 | hypothetical protein | - |
| JSQ93_RS08490 (1801753) | 1801753..1802121 | + | 369 | WP_119023792.1 | type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA | Antitoxin |
| JSQ93_RS08495 (1802210) | 1802210..1802587 | + | 378 | WP_000854690.1 | TA system toxin CbtA family protein | Toxin |
| JSQ93_RS08500 (1802584) | 1802584..1803072 | + | 489 | WP_000761699.1 | DUF5983 family protein | - |
| JSQ93_RS08505 (1803089) | 1803089..1803286 | + | 198 | WP_000839293.1 | DUF957 domain-containing protein | - |
| JSQ93_RS08510 (1803371) | 1803371..1804216 | + | 846 | WP_001529401.1 | DUF4942 domain-containing protein | - |
| JSQ93_RS08515 (1804285) | 1804285..1804680 | + | 396 | WP_000208382.1 | DUF6088 family protein | - |
| JSQ93_RS08520 (1804673) | 1804673..1805606 | + | 934 | Protein_1671 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | - |
| JSQ93_RS08525 (1806023) | 1806023..1806193 | + | 171 | Protein_1672 | IS110 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | papX / papA / papI / iucA / iucB / iucC / iucD / iutA / sat / kpsF | 1723641..1807987 | 84346 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14057.04 Da Isoelectric Point: 9.1510
>T191317 WP_000854690.1 NZ_CP069624:1802210-1802587 [Escherichia coli]
MKTLPDTHVRAASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYAQVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR
MKTLPDTHVRAASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYAQVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR
Download Length: 378 bp
>T191317 NZ_CP091677:2041942-2042118 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13601.51 Da Isoelectric Point: 4.5851
>AT191317 WP_119023792.1 NZ_CP069624:1801753-1802121 [Escherichia coli]
MSDTLPGTTLPDDNKDLPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELSPRYQHTVTLYAKGLTCEADTLGSCDYVYLAVYPTPEMKN
MSDTLPGTTLPDDNKDLPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELSPRYQHTVTLYAKGLTCEADTLGSCDYVYLAVYPTPEMKN
Download Length: 369 bp
>AT191317 NZ_CP091677:2042164-2042580 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
GCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCATGATCACTTTATTGAAGTGCCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
GCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCATGATCACTTTATTGAAGTGCCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|