Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | itaRT/DUF1778(antitoxin) |
| Location | 1319344..1320172 | Replicon | chromosome |
| Accession | NZ_CP069605 | ||
| Organism | Dickeya dianthicola strain 16JP03 | ||
Toxin (Protein)
| Gene name | itaT | Uniprot ID | A0A3A4CQM7 |
| Locus tag | JRZ92_RS06130 | Protein ID | WP_024105035.1 |
| Coordinates | 1319344..1319880 (-) | Length | 179 a.a. |
Antitoxin (Protein)
| Gene name | itaR | Uniprot ID | A0A385XV02 |
| Locus tag | JRZ92_RS06135 | Protein ID | WP_026594683.1 |
| Coordinates | 1319861..1320172 (-) | Length | 104 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JRZ92_RS06110 (JRZ92_06120) | 1314690..1315658 | + | 969 | WP_024105031.1 | o-succinylbenzoate synthase | - |
| JRZ92_RS06115 (JRZ92_06125) | 1315646..1317016 | + | 1371 | WP_024108474.1 | o-succinylbenzoate--CoA ligase | - |
| JRZ92_RS06120 (JRZ92_06130) | 1317223..1317768 | + | 546 | WP_024105033.1 | YfaZ family outer membrane protein | - |
| JRZ92_RS06125 (JRZ92_06135) | 1317991..1319184 | + | 1194 | WP_024105034.1 | nicotinamide mononucleotide deamidase-related protein YfaY | - |
| JRZ92_RS06130 (JRZ92_06140) | 1319344..1319880 | - | 537 | WP_024105035.1 | GNAT family N-acetyltransferase | Toxin |
| JRZ92_RS06135 (JRZ92_06145) | 1319861..1320172 | - | 312 | WP_026594683.1 | DUF1778 domain-containing protein | Antitoxin |
| JRZ92_RS06140 (JRZ92_06150) | 1320471..1320740 | - | 270 | Protein_1203 | IS4 family transposase | - |
| JRZ92_RS06145 (JRZ92_06155) | 1320843..1321703 | - | 861 | WP_024105037.1 | co-chaperone YbbN | - |
| JRZ92_RS06150 (JRZ92_06160) | 1321766..1322542 | - | 777 | WP_024105038.1 | SDR family oxidoreductase | - |
| JRZ92_RS06155 (JRZ92_06165) | 1322606..1323247 | - | 642 | WP_024108475.1 | multifunctional acyl-CoA thioesterase I/protease I/lysophospholipase L1 | - |
| JRZ92_RS06160 (JRZ92_06170) | 1323215..1323901 | + | 687 | WP_024107942.1 | putative ABC transporter ATP-binding protein YbbA | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 179 a.a. Molecular weight: 19327.27 Da Isoelectric Point: 6.7055
>T191262 WP_024105035.1 NZ_CP069605:c1319880-1319344 [Dickeya dianthicola]
MVDTQSESNGVVVYAYQADTTYPGSKSFDCGNTVINSFVRSSLKKSVRDGNCAAKVLVKDETKELLGFCTFAAYSLEKSK
LAGVVSGSLPHELGVVRLIMLGVATKEQNKGYGQELLLEFFKQVKTIHESLPVKGVYLDADPAAIDFYIRLGFVQLNEPP
NAFGAVPMFLAIQHILAA
MVDTQSESNGVVVYAYQADTTYPGSKSFDCGNTVINSFVRSSLKKSVRDGNCAAKVLVKDETKELLGFCTFAAYSLEKSK
LAGVVSGSLPHELGVVRLIMLGVATKEQNKGYGQELLLEFFKQVKTIHESLPVKGVYLDADPAAIDFYIRLGFVQLNEPP
NAFGAVPMFLAIQHILAA
Download Length: 537 bp
>T191262 NZ_CP091665:c856969-856592 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGCATCGCGCTGCCCGCCTCCCGTCACCATCTGGCAGACACTGCTGTC
CCGGTTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATACGGTGAACTTTCTCGTTGAAAAATACGCACTGATACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATTCTCCGGGCTCGCAGGGCAACCGGCCTGATGACCCGCGA
TAACTACAGAACGGTAAATAACATTACCCAGGGGAAACATCCGGAGGCGAAACAATGA
ATGAAAACATTACCCGACACGCATGTACGGGAGGCATCGCGCTGCCCGCCTCCCGTCACCATCTGGCAGACACTGCTGTC
CCGGTTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATACGGTGAACTTTCTCGTTGAAAAATACGCACTGATACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATTCTCCGGGCTCGCAGGGCAACCGGCCTGATGACCCGCGA
TAACTACAGAACGGTAAATAACATTACCCAGGGGAAACATCCGGAGGCGAAACAATGA
Antitoxin
Download Length: 104 a.a. Molecular weight: 11420.03 Da Isoelectric Point: 10.5508
>AT191262 WP_026594683.1 NZ_CP069605:c1320172-1319861 [Dickeya dianthicola]
MSNVSVFPNDIRVTKNARVELKTSPDLKDVLREAATAAGLDLSAFILNAALERAESVLDNQRRRQLSAASWQQLNQLLSE
PAAPTLALQALMQRKKQDGRYSK
MSNVSVFPNDIRVTKNARVELKTSPDLKDVLREAATAAGLDLSAFILNAALERAESVLDNQRRRQLSAASWQQLNQLLSE
PAAPTLALQALMQRKKQDGRYSK
Download Length: 312 bp
>AT191262 NZ_CP091665:c857427-857059 [Escherichia coli]
GTGTCAGACACACTCTCCGGGACAACGCATCCCGATGACAATCATGACCGTCCCTGGTGGGGACTACCCTGCACCGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCCGAAATGAAAAATTAA
GTGTCAGACACACTCTCCGGGACAACGCATCCCGATGACAATCATGACCGTCCCTGGTGGGGACTACCCTGCACCGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCCGAAATGAAAAATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3A4CQM7 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A385XV02 |