Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | ccdAB/CcdA(antitoxin) |
| Location | 1862755..1863308 | Replicon | chromosome |
| Accession | NZ_CP069604 | ||
| Organism | Dickeya dianthicola strain 16JP05 | ||
Toxin (Protein)
| Gene name | ccdB | Uniprot ID | A0A385XW46 |
| Locus tag | JRZ84_RS08585 | Protein ID | WP_024108344.1 |
| Coordinates | 1862994..1863308 (+) | Length | 105 a.a. |
Antitoxin (Protein)
| Gene name | ccdA | Uniprot ID | A0A385XYG1 |
| Locus tag | JRZ84_RS08580 | Protein ID | WP_024108345.1 |
| Coordinates | 1862755..1862991 (+) | Length | 79 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JRZ84_RS08545 (JRZ84_08540) | 1857839..1858252 | - | 414 | WP_024108566.1 | tautomerase family protein | - |
| JRZ84_RS08550 (JRZ84_08545) | 1858317..1858727 | - | 411 | WP_024108567.1 | hypothetical protein | - |
| JRZ84_RS08555 (JRZ84_08550) | 1858809..1859702 | - | 894 | WP_024108568.1 | alpha/beta hydrolase | - |
| JRZ84_RS08560 (JRZ84_08555) | 1859711..1860694 | - | 984 | WP_024108569.1 | MBL fold metallo-hydrolase | - |
| JRZ84_RS08565 (JRZ84_08560) | 1860960..1861445 | + | 486 | WP_024108570.1 | helix-turn-helix domain-containing protein | - |
| JRZ84_RS08570 (JRZ84_08565) | 1861541..1861675 | + | 135 | Protein_1681 | winged helix-turn-helix transcriptional regulator | - |
| JRZ84_RS08575 (JRZ84_08570) | 1861697..1862428 | + | 732 | Protein_1682 | zincin-like metallopeptidase domain-containing protein | - |
| JRZ84_RS08580 (JRZ84_08575) | 1862755..1862991 | + | 237 | WP_024108345.1 | type II toxin-antitoxin system CcdA family antitoxin | Antitoxin |
| JRZ84_RS08585 (JRZ84_08580) | 1862994..1863308 | + | 315 | WP_024108344.1 | CcdB family protein | Toxin |
| JRZ84_RS08590 (JRZ84_08585) | 1863951..1864469 | + | 519 | WP_024108343.1 | Hcp family type VI secretion system effector | - |
| JRZ84_RS08595 (JRZ84_08590) | 1864582..1866438 | + | 1857 | WP_024108342.1 | type VI secretion system tip protein VgrG | - |
| JRZ84_RS22295 | 1866464..1866748 | + | 285 | Protein_1687 | type VI secretion system PAAR protein | - |
| JRZ84_RS08605 (JRZ84_08600) | 1866988..1867863 | + | 876 | WP_024108340.1 | DUF6402 family protein | - |
| JRZ84_RS08610 (JRZ84_08605) | 1867860..1868291 | + | 432 | WP_071599229.1 | DUF6201 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | hcp | 1852588..1877464 | 24876 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 105 a.a. Molecular weight: 11487.43 Da Isoelectric Point: 7.9859
>T191247 WP_024108344.1 NZ_CP069604:1862994-1863308 [Dickeya dianthicola]
MQFTVYGNTGKSVVYPLLLDVTSDIIGQLNRRIVIPLLPVEKYPAGRRPDRLVPVVRLTDGKEYAVMTHELASIPVQALG
AVFCDASQYRTQVKAAIDFLIDGI
MQFTVYGNTGKSVVYPLLLDVTSDIIGQLNRRIVIPLLPVEKYPAGRRPDRLVPVVRLTDGKEYAVMTHELASIPVQALG
AVFCDASQYRTQVKAAIDFLIDGI
Download Length: 315 bp
>T191247 NZ_CP091664:3357441-3357827 [Escherichia coli]
ATGGGTGTGTATAAGGCAAGACGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAGGGCATATGGGAGGCTGATTTAGGTAGCGGTGTCATCAAAAAACGTTTACCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAAGAGTGGT
CTAAGCAGTAAAGGAACCAAAGAAATCGAAGATGATGAACTGGCGGCCTACAAAAAAATGGCAAATGCATTTCTGGCCTT
TAGCAATAAGCAAATAGAGGATTTGATCGAAACTGGCTTTTTGATTGAGGTGAAAAATGAGCGATAA
ATGGGTGTGTATAAGGCAAGACGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAGGGCATATGGGAGGCTGATTTAGGTAGCGGTGTCATCAAAAAACGTTTACCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAAGAGTGGT
CTAAGCAGTAAAGGAACCAAAGAAATCGAAGATGATGAACTGGCGGCCTACAAAAAAATGGCAAATGCATTTCTGGCCTT
TAGCAATAAGCAAATAGAGGATTTGATCGAAACTGGCTTTTTGATTGAGGTGAAAAATGAGCGATAA
Antitoxin
Download Length: 79 a.a. Molecular weight: 9050.09 Da Isoelectric Point: 6.7184
>AT191247 WP_024108345.1 NZ_CP069604:1862755-1862991 [Dickeya dianthicola]
MTAKQRNTQSVTMTVERALLVRAREAGINLSATLTTALDAELRRHEAKKWQEENREAIDALNRFHDEHGCFSDEYRTF
MTAKQRNTQSVTMTVERALLVRAREAGINLSATLTTALDAELRRHEAKKWQEENREAIDALNRFHDEHGCFSDEYRTF
Download Length: 237 bp
>AT191247 NZ_CP091664:3357817-3358146 [Escherichia coli]
ATGAGCGATAAATTACAAATGATGCTGGAAGATGCAAAGGAACTGAATGCACTGGGCCTGATGTCTGATAGTGAAGTTGA
TGCCATTGCCGTCATGGTCAAAGCTCGTGAAGTCAGCGCCCGTATAGCCAAAGTCAAATCAATGACGGGTGAAGAGATCA
AAGCCATCCGCACCCGATACGGCATGTCACAATCCGTGCTGGCACATACAATGGGAATGTCAAAAGAAAGTGTCTCGAAA
TGGGAACGTAATGAAATAAAACCGAGCGGCCCGGCATTACGTATTTTGAATACATTGGCAATAAAAGGGCCGGAAGTTTT
TGCAAAGTAA
ATGAGCGATAAATTACAAATGATGCTGGAAGATGCAAAGGAACTGAATGCACTGGGCCTGATGTCTGATAGTGAAGTTGA
TGCCATTGCCGTCATGGTCAAAGCTCGTGAAGTCAGCGCCCGTATAGCCAAAGTCAAATCAATGACGGGTGAAGAGATCA
AAGCCATCCGCACCCGATACGGCATGTCACAATCCGTGCTGGCACATACAATGGGAATGTCAAAAGAAAGTGTCTCGAAA
TGGGAACGTAATGAAATAAAACCGAGCGGCCCGGCATTACGTATTTTGAATACATTGGCAATAAAAGGGCCGGAAGTTTT
TGCAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A385XW46 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A385XYG1 |