Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1258942..1259567 Replicon chromosome
Accession NZ_CP069604
Organism Dickeya dianthicola strain 16JP05

Toxin (Protein)


Gene name Hha Uniprot ID E0SD87
Locus tag JRZ84_RS05905 Protein ID WP_009114000.1
Coordinates 1258942..1259145 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A3A4CQB3
Locus tag JRZ84_RS05910 Protein ID WP_024104994.1
Coordinates 1259199..1259567 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JRZ84_RS05875 (JRZ84_05865) 1254415..1254753 + 339 WP_024104989.1 P-II family nitrogen regulator -
JRZ84_RS05880 (JRZ84_05870) 1254796..1256088 + 1293 WP_024104990.1 ammonium transporter AmtB -
JRZ84_RS05885 (JRZ84_05875) 1256198..1257061 - 864 WP_024108455.1 acyl-CoA thioesterase II -
JRZ84_RS05890 (JRZ84_05880) 1257333..1257890 + 558 WP_024108456.1 YbaY family lipoprotein -
JRZ84_RS05895 (JRZ84_05885) 1257919..1258248 - 330 WP_024104993.1 MGMT family protein -
JRZ84_RS05905 (JRZ84_05895) 1258942..1259145 - 204 WP_009114000.1 HHA domain-containing protein Toxin
JRZ84_RS05910 (JRZ84_05900) 1259199..1259567 - 369 WP_024104994.1 Hha toxicity modulator TomB Antitoxin
JRZ84_RS05915 (JRZ84_05905) 1260076..1260219 - 144 WP_013316871.1 type B 50S ribosomal protein L36 -
JRZ84_RS05920 (JRZ84_05910) 1260235..1260486 - 252 WP_024108457.1 type B 50S ribosomal protein L31 -
JRZ84_RS05925 (JRZ84_05915) 1260657..1263806 - 3150 WP_024108458.1 efflux RND transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8133.51 Da        Isoelectric Point: 8.8500

>T191243 WP_009114000.1 NZ_CP069604:c1259145-1258942 [Dickeya dianthicola]
MKKIDYLMRLRKCTTIDTLERVIEKNKYELSNDELEMFYSAADHRLAELTMNKLYDKVPTAVWKYVR

Download         Length: 204 bp

>T191243 NZ_CP091664:c2668326-2668150 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTAAAACTCAG
GTTTCACGGGAGGCGCAGTGTCATGCCGCGTCACCCCAGCGAAGAGATTAAAGAACCATTGCGTAAAGCCATTCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14242.11 Da        Isoelectric Point: 5.1811

>AT191243 WP_024104994.1 NZ_CP069604:c1259567-1259199 [Dickeya dianthicola]
MDEYTPQHYDIAQLRFLCENLHDESIATLGDSSRSWVNDPTSAVNLQLNELIEHIAAFVVTYKIKYPHEAALCERVEKYL
DDTYILFSNYGINDAELQKWRKSKSQLFRMFSEKSICTVVKT

Download         Length: 369 bp

>AT191243 NZ_CP091664:c2668104-2667688 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATCAAATAGTCACGATCACTTTATTGAAGTGCCTTTGAGCGTCGCCTCTAAAGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAAAT
TACTCGCTTATTTAACTTGCACCATGCGACAAAAATCGACGCCGTCCAGCTTGCGGCTAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X3RNQ0

Antitoxin

Source ID Structure
AlphaFold DB A0A3A4CQB3

References