Detailed information of TA system TA191202

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 2368927..2369837
• Replicon: chromosome
• Accession: NZ_CP069601
• Organism: Dickeya dianthicola strain 16LI04

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: JRZ89_RS10895
• Protein ID: WP_024105930.1
• Coordinates: 2369367..2369837 (+)
• Length: 157 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A3A4C852
• Locus tag: JRZ89_RS10890
• Protein ID: WP_024105929.1
• Coordinates: 2368927..2369370 (+)
• Length: 148 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JRZ89_RS10865 (JRZ89_10860)	2363985..2364656	+	672	WP_024105924.1	dethiobiotin synthase	-
JRZ89_RS10870 (JRZ89_10865)	2364930..2365286	-	357	WP_024105925.1	DUF1283 family protein	-
JRZ89_RS10875 (JRZ89_10870)	2365492..2366241	-	750	WP_024105926.1	bifunctional NADP-dependent 3-hydroxy acid dehydrogenase/3-hydroxypropionate dehydrogenase YdfG	-
JRZ89_RS10880 (JRZ89_10875)	2366545..2367771	-	1227	WP_024105927.1	glycosyl transferase	-
JRZ89_RS10885 (JRZ89_10880)	2367790..2368617	-	828	WP_024105928.1	mannosyl-3-phosphoglycerate phosphatase-related protein	-
JRZ89_RS10890 (JRZ89_10885)	2368927..2369370	+	444	WP_024105929.1	DUF2384 domain-containing protein	Antitoxin
JRZ89_RS10895 (JRZ89_10890)	2369367..2369837	+	471	WP_024105930.1	RES family NAD+ phosphorylase	Toxin
JRZ89_RS10900 (JRZ89_10895)	2369843..2370130	+	288	WP_024105931.1	hypothetical protein	-
JRZ89_RS10905 (JRZ89_10900)	2370513..2371517	-	1005	WP_103415876.1	acyltransferase family protein	-
JRZ89_RS10910 (JRZ89_10905)	2372209..2373170	+	962	Protein_2147	dicarboxylate transporter/tellurite-resistance protein TehA	-
JRZ89_RS10915 (JRZ89_10910)	2373477..2374169	+	693	WP_223303748.1	expansin EXLX1 family cellulose-binding protein	-
JRZ89_RS10920 (JRZ89_10915)	2374463..2374780	-	318	WP_223303749.1	TetR/AcrR family transcriptional regulator C-terminal domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-148)

Antitoxin

• Antitoxin Xre (16-147)

Sequences

Toxin

Protein

• Length: 157 a.a.
• Molecular weight: 17578.95 Da
• Isoelectric Point: 4.7269

>T191202 WP_024105930.1 NZ_CP069601:2369367-2369837 [Dickeya dianthicola]
MILYRLTKTKYLSTVWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAHILDYYTLLRIDVPDDHIQSVNMN
DLPENWAEEDAPPELAAYGDAWCFTKSSIALRVPSTLSPVEFNYLLNPEHPDFSSIIQNADTIPFQFDSRLKPAIK

Nucleotide

• Length: 471 bp

>T191202 NZ_CP091659:4435090-4436412 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCAAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCCAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTGACGTTAATACCCGAAGA
CGAAACCGTAACGCATCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCGCTAGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCACAGGAGAAGACAGCACTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAATGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATGCTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCGGTGAAATA
CGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAATTCCAGGTCTTCCAGTGGTTGATTGGCGCAACGGACGGTCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTTTGGCGACAGCAAAGGTGCTGAGATTCCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCA
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAAGCAATGTGTT
GAGGTTGCATGGACGGTTAAGCCGAGAATACGGTAGTAAGTGA

Antitoxin

Protein

• Length: 148 a.a.
• Molecular weight: 16506.81 Da
• Isoelectric Point: 9.6195

>AT191202 WP_024105929.1 NZ_CP069601:2368927-2369370 [Dickeya dianthicola]
MKTFSLSTTQTRPPRLWQVAGLNNSDGVALLGQINEGLDGTVANVIIDWAKITQNDLRKMSGIPSTTFSRSRKARFTADQ
SERLVRIIRVIDRAVELFEGDKDEAQKWLNEPNRALSWKVPAELMASETGAYEVMKLITRLEHGAYS

Nucleotide

• Length: 444 bp

>AT191202 NZ_CP091659:4434824-4435090 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTGGCGAATGCAATGAAACTGGTTCGCCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATTGGTATTAAGCAGGCGACGATTTCCAATTTCGAAAACAACCCTGACAATACCACGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACGCTATGCGACGCGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAAATCTGGAGTGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A3A4C852