Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | DhiAT/dnstrm_HI1420(antitoxin) |
Location | 1628439..1629192 | Replicon | chromosome |
Accession | NZ_CP069601 | ||
Organism | Dickeya dianthicola strain 16LI04 |
Toxin (Protein)
Gene name | dhiT | Uniprot ID | A0A3A4D4W2 |
Locus tag | JRZ89_RS07575 | Protein ID | WP_024105250.1 |
Coordinates | 1628439..1628696 (+) | Length | 86 a.a. |
Antitoxin (Protein)
Gene name | dhiA | Uniprot ID | A0A3A4CVJ0 |
Locus tag | JRZ89_RS07580 | Protein ID | WP_024108578.1 |
Coordinates | 1628704..1629192 (+) | Length | 163 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
JRZ89_RS07560 (JRZ89_07550) | 1623690..1624898 | - | 1209 | WP_026595017.1 | ATP-binding protein | - |
JRZ89_RS07565 (JRZ89_07555) | 1625216..1627366 | - | 2151 | WP_024108577.1 | formate dehydrogenase subunit alpha | - |
JRZ89_RS07570 (JRZ89_07560) | 1627401..1627943 | - | 543 | WP_013317225.1 | 4Fe-4S dicluster domain-containing protein | - |
JRZ89_RS07575 (JRZ89_07565) | 1628439..1628696 | + | 258 | WP_024105250.1 | DUF4160 domain-containing protein | Toxin |
JRZ89_RS07580 (JRZ89_07570) | 1628704..1629192 | + | 489 | WP_024108578.1 | addiction module antitoxin | Antitoxin |
JRZ89_RS07585 (JRZ89_07575) | 1629327..1629824 | - | 498 | WP_024108579.1 | hydrogenase maturation peptidase HycI | - |
JRZ89_RS07590 (JRZ89_07580) | 1629817..1630215 | - | 399 | WP_024105253.1 | formate hydrogenlyase maturation HycH family protein | - |
JRZ89_RS07595 (JRZ89_07585) | 1630212..1631003 | - | 792 | WP_024108580.1 | NADH-quinone oxidoreductase subunit B family protein | - |
JRZ89_RS07600 (JRZ89_07590) | 1631000..1631569 | - | 570 | WP_103415738.1 | hydrogenase 4 subunit H | - |
JRZ89_RS07605 (JRZ89_07595) | 1631580..1633307 | - | 1728 | WP_024105256.1 | hydrogenase large subunit | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 86 a.a. Molecular weight: 10039.68 Da Isoelectric Point: 8.9654
>T191192 WP_024105250.1 NZ_CP069601:1628439-1628696 [Dickeya dianthicola]
MPEIDRLAGLIFHLYFYDDERHHLPHVHVCYGHHELIISIRTGIEIEGYLPNNKRKLALVHIRAHRQQLLSMWERAVVGR
NPGKL
MPEIDRLAGLIFHLYFYDDERHHLPHVHVCYGHHELIISIRTGIEIEGYLPNNKRKLALVHIRAHRQQLLSMWERAVVGR
NPGKL
Download Length: 258 bp
>T191192 NZ_CP091659:2606044-2606394 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GTGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTT
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GTGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTT
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA
Antitoxin
Download Length: 163 a.a. Molecular weight: 18053.72 Da Isoelectric Point: 8.0587
>AT191192 WP_024108578.1 NZ_CP069601:1628704-1629192 [Dickeya dianthicola]
MHKIVEVDVIGDFSLRLTYEDGLVCDINLYHYAPSPVFSNASQFIKFGLLPDGSLEWLPDIKLSASELRKKGEYVSHTLA
VRERNFADVISRAFYDAVIENRPEILQAALKIAVEKYGNSTVAKKAGAKSRTSLYKSLNKNTHVSLATVVSLAHTVLQLE
EK
MHKIVEVDVIGDFSLRLTYEDGLVCDINLYHYAPSPVFSNASQFIKFGLLPDGSLEWLPDIKLSASELRKKGEYVSHTLA
VRERNFADVISRAFYDAVIENRPEILQAALKIAVEKYGNSTVAKKAGAKSRTSLYKSLNKNTHVSLATVVSLAHTVLQLE
EK
Download Length: 489 bp
>AT191192 NZ_CP091659:2605799-2606050 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGCGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGCGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A3A4D4W2 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A3A4CVJ0 |