191157

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 1862759..1863312 Replicon chromosome
Accession NZ_CP069599
Organism Dickeya dianthicola strain 16MB01

Toxin (Protein)


Gene name ccdB Uniprot ID A0A385XW46
Locus tag JRZ87_RS08585 Protein ID WP_024108344.1
Coordinates 1862998..1863312 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A385XYG1
Locus tag JRZ87_RS08580 Protein ID WP_024108345.1
Coordinates 1862759..1862995 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JRZ87_RS08545 (JRZ87_08540) 1857843..1858256 - 414 WP_024108566.1 tautomerase family protein -
JRZ87_RS08550 (JRZ87_08545) 1858321..1858731 - 411 WP_024108567.1 hypothetical protein -
JRZ87_RS08555 (JRZ87_08550) 1858813..1859706 - 894 WP_024108568.1 alpha/beta hydrolase -
JRZ87_RS08560 (JRZ87_08555) 1859715..1860698 - 984 WP_024108569.1 MBL fold metallo-hydrolase -
JRZ87_RS08565 (JRZ87_08560) 1860964..1861449 + 486 WP_024108570.1 helix-turn-helix domain-containing protein -
JRZ87_RS08570 (JRZ87_08565) 1861545..1861679 + 135 Protein_1681 winged helix-turn-helix transcriptional regulator -
JRZ87_RS08575 (JRZ87_08570) 1861701..1862432 + 732 Protein_1682 zincin-like metallopeptidase domain-containing protein -
JRZ87_RS08580 (JRZ87_08575) 1862759..1862995 + 237 WP_024108345.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
JRZ87_RS08585 (JRZ87_08580) 1862998..1863312 + 315 WP_024108344.1 CcdB family protein Toxin
JRZ87_RS08590 (JRZ87_08585) 1863955..1864473 + 519 WP_024108343.1 Hcp family type VI secretion system effector -
JRZ87_RS08595 (JRZ87_08590) 1864586..1866442 + 1857 WP_024108342.1 type VI secretion system tip protein VgrG -
JRZ87_RS22295 1866468..1866752 + 285 Protein_1687 type VI secretion system PAAR protein -
JRZ87_RS08605 (JRZ87_08600) 1866992..1867867 + 876 WP_024108340.1 DUF6402 family protein -
JRZ87_RS08610 (JRZ87_08605) 1867864..1868295 + 432 WP_071599229.1 DUF6201 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - hcp 1852592..1877793 25201


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(9-78)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11487.43 Da        Isoelectric Point: 7.9859

>T191157 WP_024108344.1 NZ_CP069599:1862998-1863312 [Dickeya dianthicola]
MQFTVYGNTGKSVVYPLLLDVTSDIIGQLNRRIVIPLLPVEKYPAGRRPDRLVPVVRLTDGKEYAVMTHELASIPVQALG
AVFCDASQYRTQVKAAIDFLIDGI

Download         Length: 315 bp

>T191157 NZ_CP091652:551545-551652 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9050.09 Da        Isoelectric Point: 6.7184

>AT191157 WP_024108345.1 NZ_CP069599:1862759-1862995 [Dickeya dianthicola]
MTAKQRNTQSVTMTVERALLVRAREAGINLSATLTTALDAELRRHEAKKWQEENREAIDALNRFHDEHGCFSDEYRTF

Download         Length: 237 bp

>AT191157 NZ_CP091652:c551498-551432 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A385XW46

Antitoxin

Source ID Structure
AlphaFold DB A0A385XYG1

References