Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1258946..1259571 Replicon chromosome
Accession NZ_CP069599
Organism Dickeya dianthicola strain 16MB01

Toxin (Protein)


Gene name Hha Uniprot ID E0SD87
Locus tag JRZ87_RS05905 Protein ID WP_009114000.1
Coordinates 1258946..1259149 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A3A4CQB3
Locus tag JRZ87_RS05910 Protein ID WP_024104994.1
Coordinates 1259203..1259571 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JRZ87_RS05875 (JRZ87_05865) 1254419..1254757 + 339 WP_024104989.1 P-II family nitrogen regulator -
JRZ87_RS05880 (JRZ87_05870) 1254800..1256092 + 1293 WP_024104990.1 ammonium transporter AmtB -
JRZ87_RS05885 (JRZ87_05875) 1256202..1257065 - 864 WP_024108455.1 acyl-CoA thioesterase II -
JRZ87_RS05890 (JRZ87_05880) 1257337..1257894 + 558 WP_024108456.1 YbaY family lipoprotein -
JRZ87_RS05895 (JRZ87_05885) 1257923..1258252 - 330 WP_024104993.1 MGMT family protein -
JRZ87_RS05905 (JRZ87_05895) 1258946..1259149 - 204 WP_009114000.1 HHA domain-containing protein Toxin
JRZ87_RS05910 (JRZ87_05900) 1259203..1259571 - 369 WP_024104994.1 Hha toxicity modulator TomB Antitoxin
JRZ87_RS05915 (JRZ87_05905) 1260080..1260223 - 144 WP_013316871.1 type B 50S ribosomal protein L36 -
JRZ87_RS05920 (JRZ87_05910) 1260239..1260490 - 252 WP_024108457.1 type B 50S ribosomal protein L31 -
JRZ87_RS05925 (JRZ87_05915) 1260661..1263810 - 3150 WP_024108458.1 efflux RND transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8133.51 Da        Isoelectric Point: 8.8500

>T191153 WP_009114000.1 NZ_CP069599:c1259149-1258946 [Dickeya dianthicola]
MKKIDYLMRLRKCTTIDTLERVIEKNKYELSNDELEMFYSAADHRLAELTMNKLYDKVPTAVWKYVR

Download         Length: 204 bp

>T191153 NZ_CP091651:c4969010-4968699 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTGTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14242.11 Da        Isoelectric Point: 5.1811

>AT191153 WP_024104994.1 NZ_CP069599:c1259571-1259203 [Dickeya dianthicola]
MDEYTPQHYDIAQLRFLCENLHDESIATLGDSSRSWVNDPTSAVNLQLNELIEHIAAFVVTYKIKYPHEAALCERVEKYL
DDTYILFSNYGINDAELQKWRKSKSQLFRMFSEKSICTVVKT

Download         Length: 369 bp

>AT191153 NZ_CP091651:c4968698-4968408 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACACCCTTC
ACGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGAAC
TTATTTCCGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACTGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAGGCACTTAACCGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X3RNQ0

Antitoxin

Source ID Structure
AlphaFold DB A0A3A4CQB3

References