Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 981399..981925 Replicon chromosome
Accession NZ_CP069599
Organism Dickeya dianthicola strain 16MB01

Toxin (Protein)


Gene name ccdB Uniprot ID A0A3A4CNM8
Locus tag JRZ87_RS04570 Protein ID WP_024104817.1
Coordinates 981399..981704 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A3A4CA80
Locus tag JRZ87_RS04575 Protein ID WP_024104818.1
Coordinates 981707..981925 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JRZ87_RS04545 (JRZ87_04535) 976459..977478 + 1020 WP_024104816.1 NADP-dependent oxidoreductase -
JRZ87_RS04550 (JRZ87_04540) 977679..978683 + 1005 WP_099327157.1 IS110 family transposase -
JRZ87_RS04555 (JRZ87_04545) 978992..979195 + 204 Protein_889 transposase -
JRZ87_RS04560 (JRZ87_04550) 979185..979804 - 620 Protein_890 transposase -
JRZ87_RS04565 (JRZ87_04555) 980112..981115 - 1004 Protein_891 IS110 family transposase -
JRZ87_RS04570 (JRZ87_04560) 981399..981704 - 306 WP_024104817.1 type II toxin-antitoxin system toxin CcdB Toxin
JRZ87_RS04575 (JRZ87_04565) 981707..981925 - 219 WP_024104818.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
JRZ87_RS04580 (JRZ87_04570) 981984..982310 - 327 Protein_894 molybdopterin-guanine dinucleotide biosynthesis protein MobC -
JRZ87_RS04590 (JRZ87_04580) 982538..982720 - 183 WP_024109619.1 hypothetical protein -
JRZ87_RS04595 (JRZ87_04585) 982869..983585 - 717 WP_103415838.1 SprT family zinc-dependent metalloprotease -
JRZ87_RS04600 (JRZ87_04590) 983585..986680 - 3096 WP_103415839.1 HsdR family type I site-specific deoxyribonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11820.63 Da        Isoelectric Point: 4.6983

>T191151 WP_024104817.1 NZ_CP069599:c981704-981399 [Dickeya dianthicola]
MQFIVYQYKRASHYKMFVDVQSDIVETPKRRMVIPLIESHHLSEKVNKTLFPQIRIDGEDYRLMTTELSSVPVEVIGEEL
AELGDYADEIKDAINLMFWGI

Download         Length: 306 bp

>T191151 NZ_CP091651:c4564029-4563679 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGTGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGGTGAGGTGGTGGAAGAGGC
GTTATTACGTTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8191.17 Da        Isoelectric Point: 8.6383

>AT191151 WP_024104818.1 NZ_CP069599:c981925-981707 [Dickeya dianthicola]
MKHRVSVTVDKDNYQILSAAGVNISGLVNDAIGKEARRIKAEQWKKENREGMEEVARFIAQNGSFADENRNW

Download         Length: 219 bp

>AT191151 NZ_CP091651:c4564274-4564023 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTTCAGGTATGGTCATTCCTAATGTTGTGATGAAAGAACTTAACTTACG
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCACGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3A4CNM8

Antitoxin

Source ID Structure
AlphaFold DB A0A3A4CA80

References