Detailed information of TA system TA191150

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 733003..733681
• Replicon: chromosome
• Accession: NZ_CP069599
• Organism: Dickeya dianthicola strain 16MB01

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: JRZ87_RS03400
• Protein ID: WP_024104636.1
• Coordinates: 733250..733681 (+)
• Length: 144 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: A0A3A4CJ89
• Locus tag: JRZ87_RS03395
• Protein ID: WP_024104635.1
• Coordinates: 733003..733269 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JRZ87_RS03380 (JRZ87_03370)	730098..730706	-	609	WP_024104632.1	HD domain-containing protein	-
JRZ87_RS03385 (JRZ87_03375)	730968..731618	+	651	WP_024104633.1	hemolysin III family protein	-
JRZ87_RS03390 (JRZ87_03380)	731709..732689	-	981	WP_024104634.1	tRNA-modifying protein YgfZ	-
JRZ87_RS03395 (JRZ87_03385)	733003..733269	+	267	WP_024104635.1	FAD assembly factor SdhE	Antitoxin
JRZ87_RS03400 (JRZ87_03390)	733250..733681	+	432	WP_024104636.1	protein YgfX	Toxin
JRZ87_RS03405 (JRZ87_03395)	733776..734294	-	519	WP_024104637.1	flavodoxin FldB	-
JRZ87_RS03410 (JRZ87_03400)	734423..735748	-	1326	WP_024104638.1	MFS transporter	-
JRZ87_RS03415 (JRZ87_03405)	736011..736910	+	900	WP_024104639.1	site-specific tyrosine recombinase XerD	-
JRZ87_RS03420 (JRZ87_03410)	737000..737716	+	717	WP_024104640.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-132)

Antitoxin

• Flavinator of succinate dehydrogenase (8-79)

Sequences

Toxin

Protein

• Length: 144 a.a.
• Molecular weight: 16839.52 Da
• Isoelectric Point: 11.7737

>T191150 WP_024104636.1 NZ_CP069599:733250-733681 [Dickeya dianthicola]
VAQWQCDLRVSWRMQLFSLLTHGFLVLMILLAPWSDGYAPLWLGLVTLVVFGFVRSQRIIKSRQGEISLHGENQLHWQQR
DWQIVRRPWVMRNGVLLSLRATNGKGHQRLWLASDSMGNEEWRLLRQLLQQHPLQGTESSRHH

Nucleotide

• Length: 432 bp

>T191150 NZ_CP091651:c4552307-4552017 [Escherichia coli]
ATGAACTATGAGCTGGCGTTTGATCCGCGGGCGCTGAAAGAGTGGCAAAAACTGGGCGTGACAGTCCGGGAACAATTTAA
AAAAAAGCTTGAGGATGTGCTGAAAAGGCCGCGCAATCCATCGGCTAAACTGCGGGATTTACCGGACTGCTACAAAATTA
AGCTGCGCACACAGGGATATCGCCTGGTTTATCAGGTTAACGATAAAGAGTTGCTCGTGTTGGTGATAGCTATTGGTAAG
AGAGAGAACTCAGCCGTTTATGAAGACGCGACTAAACGGCTGGATGAGTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10471.02 Da
• Isoelectric Point: 6.0666

>AT191150 WP_024104635.1 NZ_CP069599:733003-733269 [Dickeya dianthicola]
MDINNKSRIHWACRRGMRELDISIMPFFEHEYDTLSDDDKLHFIRLLQCDDPDLFNWLMNHGEPVDPALKRMVSLIQTRN
KDRGPVAM

Nucleotide

• Length: 267 bp

>AT191150 NZ_CP091651:c4552539-4552297 [Escherichia coli]
ATGGCCACACTTAACGTCCGCCTGGATGACAAACTGAAAAATGAGGCTTATGCGGTGCTGGAAAAATTAAATATCACGCC
TACTGAAGCAGTGCGGCTGCTGTTTCAGTACGTTGCGGAAAATGGACGAATGCCGGTAAAAACGCTCACTGTCAGTGATA
GTGAAGAAGCCTTGTTACGCACTGTCAGGGAACGACTGGCCAACCCACAAGAGGCCATTAAGGTCCGACTGGATGAACTA
TGA

Structures

Antitoxin

• AlphaFold DB: A0A3A4CJ89