Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | ataRT/DUF1778(antitoxin) |
| Location | 473866..474608 | Replicon | chromosome |
| Accession | NZ_CP069599 | ||
| Organism | Dickeya dianthicola strain 16MB01 | ||
Toxin (Protein)
| Gene name | ataT | Uniprot ID | E0SIC1 |
| Locus tag | JRZ87_RS02150 | Protein ID | WP_013316117.1 |
| Coordinates | 473866..474345 (-) | Length | 160 a.a. |
Antitoxin (Protein)
| Gene name | ataR | Uniprot ID | A0A3A4C8A5 |
| Locus tag | JRZ87_RS02155 | Protein ID | WP_024104363.1 |
| Coordinates | 474336..474608 (-) | Length | 91 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JRZ87_RS02125 (JRZ87_02115) | 469086..469409 | + | 324 | WP_024104357.1 | DNA-binding transcriptional regulator | - |
| JRZ87_RS02130 (JRZ87_02120) | 469696..471423 | - | 1728 | WP_103415798.1 | retron Ec67 family RNA-directed DNA polymerase/endonuclease | - |
| JRZ87_RS02135 (JRZ87_02125) | 472544..472864 | + | 321 | WP_024104360.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| JRZ87_RS02140 (JRZ87_02130) | 472854..473138 | + | 285 | WP_024104361.1 | helix-turn-helix transcriptional regulator | - |
| JRZ87_RS22235 | 473145..473291 | + | 147 | Protein_414 | transcriptional regulator | - |
| JRZ87_RS02145 (JRZ87_02135) | 473436..473837 | - | 402 | WP_024104362.1 | hypothetical protein | - |
| JRZ87_RS02150 (JRZ87_02140) | 473866..474345 | - | 480 | WP_013316117.1 | GNAT family N-acetyltransferase | Toxin |
| JRZ87_RS02155 (JRZ87_02145) | 474336..474608 | - | 273 | WP_024104363.1 | DUF1778 domain-containing protein | Antitoxin |
| JRZ87_RS02160 (JRZ87_02150) | 475098..475521 | + | 424 | Protein_418 | Arm DNA-binding domain-containing protein | - |
| JRZ87_RS02170 (JRZ87_02160) | 476444..476650 | - | 207 | Protein_420 | DUF1778 domain-containing protein | - |
| JRZ87_RS22240 | 476721..476789 | + | 69 | Protein_421 | integrase | - |
| JRZ87_RS22245 | 476814..476906 | + | 93 | Protein_422 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | - |
| JRZ87_RS02175 (JRZ87_02165) | 476948..478336 | + | 1389 | WP_024104366.1 | hypothetical protein | - |
| JRZ87_RS02180 (JRZ87_02170) | 478486..478824 | - | 339 | WP_024104367.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 461494..480100 | 18606 | |
| - | flank | IS/Tn | - | - | 475952..476266 | 314 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 160 a.a. Molecular weight: 17564.34 Da Isoelectric Point: 9.5367
>T191149 WP_013316117.1 NZ_CP069599:c474345-473866 [Dickeya dianthicola]
VGITAPELLLPQHAVVDFHCSEPSLNEWLKRKALKNQTLGASRTFVVCEAGTQRVVGFYALASGSIQRQVAPGAFRRNMP
DPIPVLVLGRLAVDERYQRMGIGAGLLKDAVLRSRNVAQQVGNKALLVHALSDEAKAFYQYWGFVPSEIQEHTLLLSLW
VGITAPELLLPQHAVVDFHCSEPSLNEWLKRKALKNQTLGASRTFVVCEAGTQRVVGFYALASGSIQRQVAPGAFRRNMP
DPIPVLVLGRLAVDERYQRMGIGAGLLKDAVLRSRNVAQQVGNKALLVHALSDEAKAFYQYWGFVPSEIQEHTLLLSLW
Download Length: 480 bp
>T191149 NZ_CP091651:c4047096-4046698 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAGCCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGAAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAGCCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGAAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA
Antitoxin
Download Length: 91 a.a. Molecular weight: 10390.84 Da Isoelectric Point: 4.6702
>AT191149 WP_024104363.1 NZ_CP069599:c474608-474336 [Dickeya dianthicola]
MRTETKETPINIRAKASQRELIDVAAKLLSKSRTEFILDAACREAEDVLLDQRLFLVNDEQYDAFIQVLESPVTDNPRMN
ALLNRKSPWE
MRTETKETPINIRAKASQRELIDVAAKLLSKSRTEFILDAACREAEDVLLDQRLFLVNDEQYDAFIQVLESPVTDNPRMN
ALLNRKSPWE
Download Length: 273 bp
>AT191149 NZ_CP091651:c4047392-4047099 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAATCCAGCAAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CAGAACAAGAGGAGAAAAAACTGGTGAAGGCGCGCTTCCGTCCGAGTGCCGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAATCCAGCAAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CAGAACAAGAGGAGAAAAAACTGGTGAAGGCGCGCTTCCGTCCGAGTGCCGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3N0G158 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3A4C8A5 |