Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | ccdAB/CcdA(antitoxin) |
Location | 981395..981921 | Replicon | chromosome |
Accession | NZ_CP069598 | ||
Organism | Dickeya dianthicola strain 16ME21T |
Toxin (Protein)
Gene name | ccdB | Uniprot ID | A0A3A4CNM8 |
Locus tag | JRZ86_RS04570 | Protein ID | WP_024104817.1 |
Coordinates | 981395..981700 (-) | Length | 102 a.a. |
Antitoxin (Protein)
Gene name | ccdA | Uniprot ID | A0A3A4CA80 |
Locus tag | JRZ86_RS04575 | Protein ID | WP_024104818.1 |
Coordinates | 981703..981921 (-) | Length | 73 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
JRZ86_RS04545 (JRZ86_04550) | 976455..977474 | + | 1020 | WP_024104816.1 | NADP-dependent oxidoreductase | - |
JRZ86_RS04550 (JRZ86_04555) | 977675..978679 | + | 1005 | WP_099327157.1 | IS110 family transposase | - |
JRZ86_RS04555 (JRZ86_04560) | 978988..979191 | + | 204 | Protein_889 | transposase | - |
JRZ86_RS04560 (JRZ86_04565) | 979181..979800 | - | 620 | Protein_890 | transposase | - |
JRZ86_RS04565 (JRZ86_04570) | 980108..981111 | - | 1004 | Protein_891 | IS110 family transposase | - |
JRZ86_RS04570 (JRZ86_04575) | 981395..981700 | - | 306 | WP_024104817.1 | type II toxin-antitoxin system toxin CcdB | Toxin |
JRZ86_RS04575 (JRZ86_04580) | 981703..981921 | - | 219 | WP_024104818.1 | type II toxin-antitoxin system antitoxin CcdA | Antitoxin |
JRZ86_RS04580 (JRZ86_04585) | 981980..982306 | - | 327 | Protein_894 | molybdopterin-guanine dinucleotide biosynthesis protein MobC | - |
JRZ86_RS04590 (JRZ86_04595) | 982534..982716 | - | 183 | WP_024109619.1 | hypothetical protein | - |
JRZ86_RS04595 (JRZ86_04600) | 982865..983581 | - | 717 | WP_103415838.1 | SprT family zinc-dependent metalloprotease | - |
JRZ86_RS04600 (JRZ86_04605) | 983581..986676 | - | 3096 | WP_103415839.1 | HsdR family type I site-specific deoxyribonuclease | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 102 a.a. Molecular weight: 11820.63 Da Isoelectric Point: 4.6983
>T191133 WP_024104817.1 NZ_CP069598:c981700-981395 [Dickeya dianthicola]
MQFIVYQYKRASHYKMFVDVQSDIVETPKRRMVIPLIESHHLSEKVNKTLFPQIRIDGEDYRLMTTELSSVPVEVIGEEL
AELGDYADEIKDAINLMFWGI
MQFIVYQYKRASHYKMFVDVQSDIVETPKRRMVIPLIESHHLSEKVNKTLFPQIRIDGEDYRLMTTELSSVPVEVIGEEL
AELGDYADEIKDAINLMFWGI
Download Length: 306 bp
>T191133 NZ_CP091651:c843835-843458 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGGTTACTGGACCAGCATTACAGCCTTACGCTGAATGACACACCGTTCGTGGATGAACGCGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTGGAAAAATACGTACTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGCCTCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCCGGGCAACAGGTCTGATGACCCGCAG
CAACTACAGAACGGTAAATAACATTACCCGGGGGAAGCATCCGGAGGCGAAACAATGA
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGGTTACTGGACCAGCATTACAGCCTTACGCTGAATGACACACCGTTCGTGGATGAACGCGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTGGAAAAATACGTACTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGCCTCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCCGGGCAACAGGTCTGATGACCCGCAG
CAACTACAGAACGGTAAATAACATTACCCGGGGGAAGCATCCGGAGGCGAAACAATGA
Antitoxin
Download Length: 73 a.a. Molecular weight: 8191.17 Da Isoelectric Point: 8.6383
>AT191133 WP_024104818.1 NZ_CP069598:c981921-981703 [Dickeya dianthicola]
MKHRVSVTVDKDNYQILSAAGVNISGLVNDAIGKEARRIKAEQWKKENREGMEEVARFIAQNGSFADENRNW
MKHRVSVTVDKDNYQILSAAGVNISGLVNDAIGKEARRIKAEQWKKENREGMEEVARFIAQNGSFADENRNW
Download Length: 219 bp
>AT191133 NZ_CP091651:c844293-843925 [Escherichia coli]
GTGTCAGACACACTCTCCGGGACAACGCATCCCGATGACAATCACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTAACAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA
GTGTCAGACACACTCTCCGGGACAACGCATCCCGATGACAATCACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTAACAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A3A4CNM8 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A3A4CA80 |