Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 981395..981921 Replicon chromosome
Accession NZ_CP069598
Organism Dickeya dianthicola strain 16ME21T

Toxin (Protein)


Gene name ccdB Uniprot ID A0A3A4CNM8
Locus tag JRZ86_RS04570 Protein ID WP_024104817.1
Coordinates 981395..981700 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A3A4CA80
Locus tag JRZ86_RS04575 Protein ID WP_024104818.1
Coordinates 981703..981921 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JRZ86_RS04545 (JRZ86_04550) 976455..977474 + 1020 WP_024104816.1 NADP-dependent oxidoreductase -
JRZ86_RS04550 (JRZ86_04555) 977675..978679 + 1005 WP_099327157.1 IS110 family transposase -
JRZ86_RS04555 (JRZ86_04560) 978988..979191 + 204 Protein_889 transposase -
JRZ86_RS04560 (JRZ86_04565) 979181..979800 - 620 Protein_890 transposase -
JRZ86_RS04565 (JRZ86_04570) 980108..981111 - 1004 Protein_891 IS110 family transposase -
JRZ86_RS04570 (JRZ86_04575) 981395..981700 - 306 WP_024104817.1 type II toxin-antitoxin system toxin CcdB Toxin
JRZ86_RS04575 (JRZ86_04580) 981703..981921 - 219 WP_024104818.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
JRZ86_RS04580 (JRZ86_04585) 981980..982306 - 327 Protein_894 molybdopterin-guanine dinucleotide biosynthesis protein MobC -
JRZ86_RS04590 (JRZ86_04595) 982534..982716 - 183 WP_024109619.1 hypothetical protein -
JRZ86_RS04595 (JRZ86_04600) 982865..983581 - 717 WP_103415838.1 SprT family zinc-dependent metalloprotease -
JRZ86_RS04600 (JRZ86_04605) 983581..986676 - 3096 WP_103415839.1 HsdR family type I site-specific deoxyribonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11820.63 Da        Isoelectric Point: 4.6983

>T191133 WP_024104817.1 NZ_CP069598:c981700-981395 [Dickeya dianthicola]
MQFIVYQYKRASHYKMFVDVQSDIVETPKRRMVIPLIESHHLSEKVNKTLFPQIRIDGEDYRLMTTELSSVPVEVIGEEL
AELGDYADEIKDAINLMFWGI

Download         Length: 306 bp

>T191133 NZ_CP091651:c843835-843458 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGGTTACTGGACCAGCATTACAGCCTTACGCTGAATGACACACCGTTCGTGGATGAACGCGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTGGAAAAATACGTACTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGCCTCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCCGGGCAACAGGTCTGATGACCCGCAG
CAACTACAGAACGGTAAATAACATTACCCGGGGGAAGCATCCGGAGGCGAAACAATGA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8191.17 Da        Isoelectric Point: 8.6383

>AT191133 WP_024104818.1 NZ_CP069598:c981921-981703 [Dickeya dianthicola]
MKHRVSVTVDKDNYQILSAAGVNISGLVNDAIGKEARRIKAEQWKKENREGMEEVARFIAQNGSFADENRNW

Download         Length: 219 bp

>AT191133 NZ_CP091651:c844293-843925 [Escherichia coli]
GTGTCAGACACACTCTCCGGGACAACGCATCCCGATGACAATCACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTAACAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3A4CNM8

Antitoxin

Source ID Structure
AlphaFold DB A0A3A4CA80

References