191121

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 1862755..1863308 Replicon chromosome
Accession NZ_CP069597
Organism Dickeya dianthicola strain 16ME22T

Toxin (Protein)


Gene name ccdB Uniprot ID A0A385XW46
Locus tag JRZ88_RS08590 Protein ID WP_024108344.1
Coordinates 1862994..1863308 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A385XYG1
Locus tag JRZ88_RS08585 Protein ID WP_024108345.1
Coordinates 1862755..1862991 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JRZ88_RS08550 (JRZ88_08560) 1857839..1858252 - 414 WP_024108566.1 tautomerase family protein -
JRZ88_RS08555 (JRZ88_08565) 1858317..1858727 - 411 WP_024108567.1 hypothetical protein -
JRZ88_RS08560 (JRZ88_08570) 1858809..1859702 - 894 WP_024108568.1 alpha/beta hydrolase -
JRZ88_RS08565 (JRZ88_08575) 1859711..1860694 - 984 WP_024108569.1 MBL fold metallo-hydrolase -
JRZ88_RS08570 (JRZ88_08580) 1860960..1861445 + 486 WP_024108570.1 helix-turn-helix domain-containing protein -
JRZ88_RS08575 (JRZ88_08585) 1861541..1861675 + 135 Protein_1682 winged helix-turn-helix transcriptional regulator -
JRZ88_RS08580 (JRZ88_08590) 1861697..1862428 + 732 Protein_1683 zincin-like metallopeptidase domain-containing protein -
JRZ88_RS08585 (JRZ88_08595) 1862755..1862991 + 237 WP_024108345.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
JRZ88_RS08590 (JRZ88_08600) 1862994..1863308 + 315 WP_024108344.1 CcdB family protein Toxin
JRZ88_RS08595 (JRZ88_08605) 1863951..1864469 + 519 WP_024108343.1 Hcp family type VI secretion system effector -
JRZ88_RS08600 (JRZ88_08610) 1864582..1866438 + 1857 WP_024108342.1 type VI secretion system tip protein VgrG -
JRZ88_RS22310 1866464..1866748 + 285 Protein_1688 type VI secretion system PAAR protein -
JRZ88_RS08610 (JRZ88_08620) 1866988..1867863 + 876 WP_024108340.1 DUF6402 family protein -
JRZ88_RS08615 (JRZ88_08625) 1867860..1868291 + 432 WP_071599229.1 DUF6201 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - hcp 1852588..1877464 24876


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(9-78)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11487.43 Da        Isoelectric Point: 7.9859

>T191121 WP_024108344.1 NZ_CP069597:1862994-1863308 [Dickeya dianthicola]
MQFTVYGNTGKSVVYPLLLDVTSDIIGQLNRRIVIPLLPVEKYPAGRRPDRLVPVVRLTDGKEYAVMTHELASIPVQALG
AVFCDASQYRTQVKAAIDFLIDGI

Download         Length: 315 bp

>T191121 NZ_CP091650:c2375257-2374340 [Klebsiella pneumoniae]
ATGGATATACAGGCGCCTTATTATCGGCAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACTGCCATCAATCTCTTTATCCGCGATTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCACCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGTGTA
TTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAATCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTTTCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9050.09 Da        Isoelectric Point: 6.7184

>AT191121 WP_024108345.1 NZ_CP069597:1862755-1862991 [Dickeya dianthicola]
MTAKQRNTQSVTMTVERALLVRAREAGINLSATLTTALDAELRRHEAKKWQEENREAIDALNRFHDEHGCFSDEYRTF

Download         Length: 237 bp

>AT191121 NZ_CP091650:c2376021-2375263 [Klebsiella pneumoniae]
ATGGCAACAAAATTAAACTGGCTGCTGCAAAACAGCGCTCCCGGAGATGTGATCCTTCAGTCCTGGTTAAGCCAGCATGC
CATCTCTCCCTCTCTGGCCTTTAAATACGCGCAAAGTGGCTGGTTAAAAAAAAGAGGCAACGGCGTATATGCGCGTGCGG
GACGTGAGCCGGAGTGGAACGATGCATTTGCATGTTTGCAAAATCAGCTTGCCGCTCCGGTGTATGTTGCGGGGCTCAGT
AGCTTAGTCTGGCAGGGCCGTTCACACTATCTACAGCTAAAACAAAACCAGTGCTGGCTTAGTGTGGAAAATAAAGCGCT
GCTGCCGAAATGGTTCAGGGAATTCCCGGGTGTGGAGTGGATAGTCATATCGGGGAAAAAACTGCCGGTGCTGGATGATA
GATACCGTGTAACGCTTGATATAAAAGGGAAAAAACTCATCGGCAGTGCGCCAGAACTGGCTGCTTACGAGTTGCTGAGC
GCGGTGCCGGGGACCCTCTCATTTAACCACGCTGCAGAGCTTTTCCAGGGGCTGGTTAATCTTAATCCTCGTAAAGTAGA
GTATCTTCTTTCCGTCAGCCAGTCCGTGCAGGCCAAGCGTTTGTATCTCTTCTTCGCCAGTTTTTACGAGCATGGCTGGC
TCAAACGAATCGATAGCCAAAAAATCGATCTGGGAGCGGGCAAGCGGCAAATCGTGGAAAATGGAAAGTTCAATGCTCAA
TACCAAATCACAGTGCCTGAACGCTTTCAAAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A385XW46

Antitoxin

Source ID Structure
AlphaFold DB A0A385XYG1

References