Detailed information of TA system TA191114

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 732999..733677
• Replicon: chromosome
• Accession: NZ_CP069597
• Organism: Dickeya dianthicola strain 16ME22T

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: JRZ88_RS03405
• Protein ID: WP_024104636.1
• Coordinates: 733246..733677 (+)
• Length: 144 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: A0A3A4CJ89
• Locus tag: JRZ88_RS03400
• Protein ID: WP_024104635.1
• Coordinates: 732999..733265 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JRZ88_RS03385 (JRZ88_03380)	730094..730702	-	609	WP_024104632.1	HD domain-containing protein	-
JRZ88_RS03390 (JRZ88_03385)	730964..731614	+	651	WP_024104633.1	hemolysin III family protein	-
JRZ88_RS03395 (JRZ88_03390)	731705..732685	-	981	WP_024104634.1	tRNA-modifying protein YgfZ	-
JRZ88_RS03400 (JRZ88_03395)	732999..733265	+	267	WP_024104635.1	FAD assembly factor SdhE	Antitoxin
JRZ88_RS03405 (JRZ88_03400)	733246..733677	+	432	WP_024104636.1	protein YgfX	Toxin
JRZ88_RS03410 (JRZ88_03405)	733772..734290	-	519	WP_024104637.1	flavodoxin FldB	-
JRZ88_RS03415 (JRZ88_03410)	734419..735744	-	1326	WP_024104638.1	MFS transporter	-
JRZ88_RS03420 (JRZ88_03415)	736007..736906	+	900	WP_024104639.1	site-specific tyrosine recombinase XerD	-
JRZ88_RS03425 (JRZ88_03420)	736996..737712	+	717	WP_024104640.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-132)

Antitoxin

• Flavinator of succinate dehydrogenase (8-79)

Sequences

Toxin

Protein

• Length: 144 a.a.
• Molecular weight: 16839.52 Da
• Isoelectric Point: 11.7737

>T191114 WP_024104636.1 NZ_CP069597:733246-733677 [Dickeya dianthicola]
VAQWQCDLRVSWRMQLFSLLTHGFLVLMILLAPWSDGYAPLWLGLVTLVVFGFVRSQRIIKSRQGEISLHGENQLHWQQR
DWQIVRRPWVMRNGVLLSLRATNGKGHQRLWLASDSMGNEEWRLLRQLLQQHPLQGTESSRHH

Nucleotide

• Length: 432 bp

>T191114 NZ_CP091649:159668-160018 [Burkholderia aenigmatica]
ATGGTAAAGCGGGTCAAGTTCGATCGGGGCGACATCGTGCGCGTTAGCCTGAACCGGACCATCGGGCGCGAGCAGCAGGG
CGATTTCCGTCCCGCGCTTGTGCTGTCTCCCGCCGCATTCAATGCCTTGGGGGTGGCGCTCGTCGCGCCGATCACGCAGG
GCGGGGAGTTTGCGCGCTTCGCAGGATTCGCCGTGCCGCTCTCTGGCTCGGGCACCGAGACGCAGGGCGTGGCCTTGGTG
AACATGGTCCGGATGCTCGATCTGGAGGCGCGTGGCGCACGGACGATCGAGCGGGCTCCGGCCGAGGTGGTCGAAGATGC
GCTGGCTCGGCTGCAATCGATAATCGAGTAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10471.02 Da
• Isoelectric Point: 6.0666

>AT191114 WP_024104635.1 NZ_CP069597:732999-733265 [Dickeya dianthicola]
MDINNKSRIHWACRRGMRELDISIMPFFEHEYDTLSDDDKLHFIRLLQCDDPDLFNWLMNHGEPVDPALKRMVSLIQTRN
KDRGPVAM

Nucleotide

• Length: 267 bp

>AT191114 NZ_CP091649:159423-159674 [Burkholderia aenigmatica]
ATGGAACTAAAAATTCAGAAATGGGGCAACAGTGCGGCGGTGCGACTCCCCGCCGTGTTGCTCGAGCAGATGCACGCCTC
GGTCGGCGGCTCGCTGAACGCCGACGTGCGTCCGGACGGCGTATTGCTGACCCCCGCGCGCCGCAAGTATGCGCTGGACG
AACTGGTCGCTCAGTGTGATGCGAAAGCGCCTTTCCCGGCGGACATGGCTGCATGGGGTGAGGTCAGGCCGGTAGGGCGT
GAAGGATGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A3A4CJ89