Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 1578095..1578648 Replicon chromosome
Accession NZ_CP069595
Organism Dickeya dianthicola strain PA24

Toxin (Protein)


Gene name ccdB Uniprot ID A0A3A4C6R7
Locus tag JRZ93_RS07360 Protein ID WP_024108941.1
Coordinates 1578334..1578648 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A3A4CC32
Locus tag JRZ93_RS07355 Protein ID WP_024108942.1
Coordinates 1578095..1578331 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JRZ93_RS07345 (JRZ93_07340) 1574896..1576125 - 1230 WP_024108553.1 DNA cytosine methyltransferase -
JRZ93_RS07350 (JRZ93_07345) 1576824..1577768 + 945 WP_116587116.1 zincin-like metallopeptidase domain-containing protein -
JRZ93_RS07355 (JRZ93_07350) 1578095..1578331 + 237 WP_024108942.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
JRZ93_RS07360 (JRZ93_07355) 1578334..1578648 + 315 WP_024108941.1 CcdB family protein Toxin
JRZ93_RS07365 (JRZ93_07360) 1579128..1579910 + 783 WP_024108940.1 hypothetical protein -
JRZ93_RS07370 (JRZ93_07365) 1580197..1580943 - 747 WP_103415724.1 MobC family replication-relaxation protein -
JRZ93_RS07375 (JRZ93_07370) 1580952..1582715 - 1764 WP_103415725.1 type IV secretion system DNA-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - hcp 1548924..1611574 62650


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(9-78)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11457.41 Da        Isoelectric Point: 7.9859

>T191083 WP_024108941.1 NZ_CP069595:1578334-1578648 [Dickeya dianthicola]
MQFTVYGNTGKSVVYPLLLDVTSDIIGQLNRRIVIPLLPVEKYPAGRRPDRLVPVVRLTDGKEYAVMAHELASIPVQALG
AVFCDASQYRTQVKAAIDFLIDGI

Download         Length: 315 bp

>T191083 NZ_CP091636:c1008577-1008050 [Salmonella enterica]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGAAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGGGATACGATGTGCCAGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGTGGCGTAGCCCTGCTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTACTG
TCGTTTAAAACGCTTTATGCGGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9067.12 Da        Isoelectric Point: 5.8500

>AT191083 WP_024108942.1 NZ_CP069595:1578095-1578331 [Dickeya dianthicola]
MTAKQRNTQSVTMTVERALLLRAREAGINLSATLTTALDAELRRYEAKKWQEENREAIDALNRFHDENGCFSDEYRTF

Download         Length: 237 bp

>AT191083 NZ_CP091636:c1008864-1008574 [Salmonella enterica]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGGCTGTCGTTGCGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACGTACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGCGATACTCAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCCGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3A4C6R7

Antitoxin

Source ID Structure
AlphaFold DB A0A3A4CC32

References