Detailed information of TA system TA191076

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1730944..1731559
• Replicon: chromosome
• Accession: NZ_CP069594
• Organism: Pseudomonas sp. Y39-6

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A0R3AY05
• Locus tag: JN756_RS07805
• Protein ID: WP_057004762.1
• Coordinates: 1731377..1731559 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: JN756_RS07800
• Protein ID: WP_079443027.1
• Coordinates: 1730944..1731354 (-)
• Length: 137 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JN756_RS07765 (JN756_07700)	1726297..1726974	+	678	WP_126589327.1	NAD(P)H-binding protein	-
JN756_RS07770 (JN756_07705)	1726975..1727463	-	489	WP_046384399.1	DMT family transporter	-
JN756_RS07775 (JN756_07710)	1727532..1728458	+	927	WP_046384398.1	LysR family transcriptional regulator	-
JN756_RS07780 (JN756_07715)	1728472..1728882	+	411	WP_046384397.1	fosfomycin resistance glutathione transferase	-
JN756_RS07785 (JN756_07720)	1728937..1729578	+	642	WP_046384396.1	LysE family translocator	-
JN756_RS07790 (JN756_07725)	1729695..1730222	+	528	WP_017844866.1	DUF4142 domain-containing protein	-
JN756_RS07795 (JN756_07730)	1730315..1730815	-	501	WP_046490294.1	methylated-DNA--[protein]-cysteine S-methyltransferase	-
JN756_RS07800 (JN756_07735)	1730944..1731354	-	411	WP_079443027.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
JN756_RS07805 (JN756_07740)	1731377..1731559	-	183	WP_057004762.1	type II toxin-antitoxin system HicA family toxin	Toxin
JN756_RS07810 (JN756_07745)	1731707..1732609	-	903	WP_046384393.1	LysR family transcriptional regulator	-
JN756_RS07815 (JN756_07750)	1732705..1733868	+	1164	WP_201021971.1	MFS transporter	-
JN756_RS07820 (JN756_07755)	1733865..1735058	+	1194	WP_126589324.1	MFS transporter	-
JN756_RS07825 (JN756_07760)	1735140..1735508	-	369	WP_057004765.1	BrnA antitoxin family protein	-
JN756_RS07830 (JN756_07765)	1735477..1735794	-	318	WP_082643845.1	BrnT family toxin	-
JN756_RS07835 (JN756_07770)	1736018..1736323	-	306	WP_017844869.1	DUF6482 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (6-57)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-128)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6767.99 Da
• Isoelectric Point: 10.7532

>T191076 WP_057004762.1 NZ_CP069594:c1731559-1731377 [Pseudomonas sp. Y39-6]
VDSRYLIGHIVADGWYLVRVRGSHHPFKHPTKPGLVTIPHPKKDLLDKTAKSMLKQALLS

Nucleotide

• Length: 183 bp

>T191076 NZ_CP091634:3533267-3533512 [Salmonella enterica]
ATGAATGCCTCCGGCGTCAGCGTCCGCCACATCAACAGCGAAACCTGCATGACCGCCTGTTACTCACAAATCCCCAGCGG
CGACTGCCAGGAAGAAGCGGGATTTGAGACCGGGCGCAGCGTGACGGTGAAGATTTCGGACGGGTGTATTGTGCTAATGG
CGGACGGTAACGAGGTGCAGAAGCTGTGCGAACAGCTTTATCAGGCTGAACAGGTAGTTAAGGGGATGTGGGACGTGATT
GTTTAG

Antitoxin

Protein

• Length: 137 a.a.
• Molecular weight: 14804.78 Da
• Isoelectric Point: 4.5036

>AT191076 WP_079443027.1 NZ_CP069594:c1731354-1730944 [Pseudomonas sp. Y39-6]
VLYPIAISTGDEDHAWGVEVPDIPGCYSAGDDLDDAMAMAREAIEGHFEILAEDGAPIPSAQKVTLHAANPKYAGCMWAV
VDIDVTKYLGKAQKLNITLPGYLLNRIDEYVLHHPEEKSRSGFLASAALKVLQQDR

Nucleotide

• Length: 411 bp

>AT191076 NZ_CP091634:c3533476-3533120 [Salmonella enterica]
TTCAGCCTGATAAAGCTGTTCGCACAGCTTCTGCACCTCGTTACCGTCCGCCATTAGCACAATACACCCGTCCGAAATCT
TCACCGTCACGCTGCGCCCGGTCTCAAATCCCGCTTCTTCCTGGCAGTCGCCGCTGGGGATTTGTGAGTAACAGGCGGTC
ATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTC
CGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTGAGCGAGTATGGGCGCGACATCCTGGCATCGCGCCTCTCTCTCCCCG
GCCAGTGATGAGCAACCGGCTGCCGGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A0R3AY05