191066

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 46882..47441 Replicon plasmid unnamed1
Accession NZ_CP069590
Organism Escherichia coli strain FDAARGOS_1266

Toxin (Protein)


Gene name relE Uniprot ID V0SVC8
Locus tag I6J96_RS24925 Protein ID WP_000421272.1
Coordinates 47166..47441 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V0SRR3
Locus tag I6J96_RS24920 Protein ID WP_001387467.1
Coordinates 46882..47166 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6J96_RS24895 42345..42785 - 441 Protein_43 zinc-binding dehydrogenase -
I6J96_RS24900 43186..44076 + 891 WP_001077068.1 dihydrodipicolinate synthase family protein -
I6J96_RS24905 44101..44481 + 381 WP_000710783.1 Rid family detoxifying hydrolase -
I6J96_RS24910 44514..45479 + 966 WP_001022265.1 2-keto-3-deoxygluconate transporter -
I6J96_RS24915 45525..46277 - 753 WP_000562172.1 IclR family transcriptional regulator -
I6J96_RS24920 46882..47166 + 285 WP_001387467.1 ribbon-helix-helix domain-containing protein Antitoxin
I6J96_RS24925 47166..47441 + 276 WP_000421272.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6J96_RS24930 47547..47840 + 294 WP_001105060.1 hypothetical protein -
I6J96_RS24935 47875..48003 - 129 Protein_51 IS481 family transposase -
I6J96_RS24940 48036..49205 - 1170 WP_001072355.1 hypothetical protein -
I6J96_RS24945 49698..50005 + 308 Protein_53 type II toxin-antitoxin system ParD family antitoxin -
I6J96_RS24950 50294..50991 + 698 Protein_54 IS1 family transposase -
I6J96_RS24955 51245..52267 - 1023 WP_000361402.1 helicase UvrD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid aac(6')-Ib-cr / blaOXA-1 / blaTEM-1B / tet(A) / blaCTX-M-15 - 1..127965 127965
- flank IS/Tn - - 50488..50991 503


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(14-51)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10749.45 Da        Isoelectric Point: 10.0871

>T191066 WP_000421272.1 NZ_CP069590:47166-47441 [Escherichia coli]
MELKWTSKALSDLSRLFDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFAGEYEIRYEINGQTIY
VLRLWHTRENR

Download         Length: 276 bp

>T191066 NZ_CP091630:c4040628-4040344 [Salmonella enterica]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGACGATACGGTGAAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCCGTTTAAACGGTCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGTCTGGTGTACCAGGTTCGGGATGAAGTTGTGATTGTGTTTGTTGTTGCGGTCGGCAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10460.87 Da        Isoelectric Point: 5.6558

>AT191066 WP_001387467.1 NZ_CP069590:46882-47166 [Escherichia coli]
MQMKNNAAQATKVITAHVPLPMADKVDQMAARLERSRGWVIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQAW
SDSLSTDNPLPVPR

Download         Length: 285 bp

>AT191066 NZ_CP091630:c4040860-4040618 [Salmonella enterica]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACTCTTAGCGACA
GTGAAGATGCATTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SVC8

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0Y880

References