Detailed information of TA system TA191060

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 4072379..4073199
• Replicon: chromosome
• Accession: NZ_CP069589
• Organism: Escherichia coli strain FDAARGOS_1266

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: B6I030
• Locus tag: I6J96_RS19870
• Protein ID: WP_001054379.1
• Coordinates: 4072942..4073199 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: I6J96_RS19865
• Protein ID: WP_000123957.1
• Coordinates: 4072379..4072930 (-)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6J96_RS19835	4068073..4069386	-	1314	WP_000460845.1	galactitol-specific PTS transporter subunit IIC	-
I6J96_RS19840	4069398..4069676	-	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
I6J96_RS19845	4069673..4070794	-	1122	WP_000010833.1	M42 family metallopeptidase	-
I6J96_RS19850	4071039..4071155	-	117	Protein_3881	VOC family protein	-
I6J96_RS19855	4071193..4071453	-	261	WP_000077645.1	hypothetical protein	-
I6J96_RS19860	4071581..4072327	-	747	WP_000354249.1	class I SAM-dependent methyltransferase	-
I6J96_RS19865	4072379..4072930	-	552	WP_000123957.1	N-acetyltransferase	Antitoxin
I6J96_RS19870	4072942..4073199	-	258	WP_001054379.1	YjhX family toxin	Toxin
I6J96_RS19875	4073576..4073740	-	165	Protein_3886	GNAT family N-acetyltransferase	-
I6J96_RS19885	4075021..4075446	+	426	WP_000422741.1	IS66 family insertion sequence hypothetical protein	-
I6J96_RS19890	4075443..4075793	+	351	WP_000624722.1	IS66 family insertion sequence element accessory protein TnpB	-
I6J96_RS19895	4075824..4077437	+	1614	WP_000080195.1	IS66-like element ISEc23 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (19-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9568.07 Da
• Isoelectric Point: 11.1381

>T191060 WP_001054379.1 NZ_CP069589:c4073199-4072942 [Escherichia coli]
MNLSRQEQRTLHVLAKGGRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Nucleotide

• Length: 258 bp

>T191060 NZ_CP091630:317650-318003 [Salmonella enterica]
ATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGGCATGCCTGATCCTGG
GCGCGCGGAAGCGCTAATGTACCGGGTACTCAATCAAATCGAATATGAAGGGGTGACCGACGTGTGGCTGCTGGCGGCAA
TGCATTTGCTCGCTATATCCCGTGGGCATATCTTCAATGATGGTAACAAACGTACCGCCTTATTTATTACGCTGCTGTTT
TTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCGGATTTTGTCGATATGACAGTCGATGCGGCGGCAGGGCGGCTTAC
GCTGGAGCAAATTGTCGTTCGCTTACGCGCCTGA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20358.34 Da
• Isoelectric Point: 6.4182

>AT191060 WP_000123957.1 NZ_CP069589:c4072930-4072379 [Escherichia coli]
MTAHHFTFQITDESDASDIREVETRAFGFSKEADLTASLLEDESARPALSLLARHEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQALTA
QPMNVTGHIQCAQALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT191060 NZ_CP091630:317416-317637 [Salmonella enterica]
ATGCGTACGGTTAACTATAGCGAAGCGCGGCAAAATCTGGCCGAAGTCCTGGAAAGTGCGGTGACGGGGGGCCCTGTCAC
CATCACGCGTCGTGGGCATAAGTCCGCAGTGATCATCAGCGCCGAGGAGTTTGAGCGTTATCAGACGGCGCGAATGGATG
ATGAGTTTGCTGCCATTATGGCGGTTCATGGCAATGAGCTCAGGGAGCTGGCGGATAAATGA

Structures

Toxin

• AlphaFold DB: B6I030