Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 3944183..3944778 Replicon chromosome
Accession NZ_CP069589
Organism Escherichia coli strain FDAARGOS_1266

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag I6J96_RS19235 Protein ID WP_000239579.1
Coordinates 3944428..3944778 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag I6J96_RS19230 Protein ID WP_001223208.1
Coordinates 3944183..3944434 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6J96_RS19220 3939848..3943627 + 3780 WP_000060945.1 autotransporter assembly complex protein TamB -
I6J96_RS19225 3943630..3943971 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
I6J96_RS19230 3944183..3944434 + 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
I6J96_RS19235 3944428..3944778 + 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
I6J96_RS19240 3944858..3945388 - 531 WP_000055075.1 inorganic diphosphatase -
I6J96_RS19245 3945698..3946654 + 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
I6J96_RS19250 3946794..3948296 + 1503 WP_000205813.1 sugar ABC transporter ATP-binding protein -
I6J96_RS19255 3948310..3949332 + 1023 WP_001296689.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T191058 WP_000239579.1 NZ_CP069589:3944428-3944778 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T191058 NZ_CP091628:6055-138 [Salmonella enterica]

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT191058 WP_001223208.1 NZ_CP069589:3944183-3944434 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT191058 NZ_CP091628:5913-6005 [Salmonella enterica]
AGGTGATTTGCTACCTTTAAGTGCAGCTAGAAATTCAGGTGATTTGCTACCTTAAGTGCAGCTAGAAATTTAGGTCATTT
ACTACCTTAAAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References