191048

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1372036..1372867 Replicon chromosome
Accession NZ_CP069589
Organism Escherichia coli strain FDAARGOS_1266

Toxin (Protein)


Gene name yeeV Uniprot ID A0A066T988
Locus tag I6J96_RS07160 Protein ID WP_000854815.1
Coordinates 1372493..1372867 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A061Y7A8
Locus tag I6J96_RS07155 Protein ID WP_001280918.1
Coordinates 1372036..1372404 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6J96_RS07110 1367125..1367871 + 747 WP_001016257.1 IS21-like element ISEc12 family helper ATPase IstB -
I6J96_RS07115 1367954..1368304 + 351 Protein_1403 hypothetical protein -
I6J96_RS07120 1368320..1368730 + 411 WP_000846703.1 hypothetical protein -
I6J96_RS07125 1368951..1369769 + 819 WP_001542275.1 DUF945 domain-containing protein -
I6J96_RS07130 1369769..1370014 + 246 WP_001164966.1 hypothetical protein -
I6J96_RS07135 1370108..1370581 + 474 WP_001542276.1 antirestriction protein -
I6J96_RS07140 1370597..1371073 + 477 WP_001186200.1 RadC family protein -
I6J96_RS07145 1371136..1371357 + 222 WP_000692345.1 DUF987 domain-containing protein -
I6J96_RS07150 1371376..1372020 + 645 WP_000086752.1 hypothetical protein -
I6J96_RS07155 1372036..1372404 + 369 WP_001280918.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
I6J96_RS07160 1372493..1372867 + 375 WP_000854815.1 type IV toxin-antitoxin system toxin CbtA Toxin
I6J96_RS07165 1372864..1373058 + 195 WP_000988600.1 hypothetical protein -
I6J96_RS07170 1373071..1373184 + 114 WP_001161660.1 DUF957 domain-containing protein -
I6J96_RS07175 1373473..1373619 - 147 Protein_1415 transposase domain-containing protein -
I6J96_RS07180 1373673..1373855 + 183 WP_001296208.1 hypothetical protein -
I6J96_RS07185 1373956..1374285 - 330 WP_000450409.1 DUF496 family protein -
I6J96_RS07190 1374457..1375515 - 1059 WP_001200889.1 FUSC family protein -
I6J96_RS07195 1375713..1376186 - 474 WP_001105368.1 DNA gyrase inhibitor SbmC -
I6J96_RS07200 1376305..1377471 - 1167 WP_001296209.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13829.83 Da        Isoelectric Point: 7.1326

>T191048 WP_000854815.1 NZ_CP069589:1372493-1372867 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTSDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T191048 NZ_CP091626:213723-214208 [Salmonella enterica]
GTGGGACGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTAGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTCAACCATACAGAAGCGACAGGCAACCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGGAAAAGGGCTTGGGGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACATTGTTCCTTAGGCTCCCT
CAATAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13811.70 Da        Isoelectric Point: 6.4767

>AT191048 WP_001280918.1 NZ_CP069589:1372036-1372404 [Escherichia coli]
VSDKLHETNYPDDHNDRLWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT191048 NZ_CP091626:213448-213735 [Salmonella enterica]
ATGCTATACAAAGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAATCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAACGGCCTGCCGGGCTGCCGAGAATGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGAGGAGTTCATTAATCTGCTTGATGCACCGGTCGCAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A066T988

Antitoxin

Source ID Structure
AlphaFold DB A0A061Y7A8

References