Detailed information of TA system TA191034

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 28651..30265
• Replicon: plasmid unnamed
• Accession: NZ_CP069588
• Organism: Chromobacterium violaceum strain FDAARGOS_1273

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: I6K03_RS22680
• Protein ID: WP_204086889.1
• Coordinates: 28916..30265 (+)
• Length: 450 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: I6K03_RS22675
• Protein ID: WP_048404587.1
• Coordinates: 28651..28914 (+)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6K03_RS22660	24543..25451	-	909	WP_204086886.1	TniB family NTP-binding protein	-
I6K03_RS22665	25454..27133	-	1680	WP_204086887.1	DDE-type integrase/transposase/recombinase	-
I6K03_RS22670	27325..27948	+	624	WP_204086888.1	recombinase family protein	-
I6K03_RS22675	28651..28914	+	264	WP_048404587.1	helix-turn-helix domain-containing protein	Antitoxin
I6K03_RS22680	28916..30265	+	1350	WP_204086889.1	type II toxin-antitoxin system HipA family toxin	Toxin
I6K03_RS22685	30574..31755	-	1182	WP_204086890.1	replication initiator protein A	-
I6K03_RS22690	32121..32948	+	828	WP_043616644.1	AAA family ATPase	-
I6K03_RS22695	32932..33837	+	906	WP_043616641.1	ParB/RepB/Spo0J family partition protein	-
I6K03_RS22700	33861..34811	+	951	WP_204086891.1	replication initiator protein A	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..49107	49107

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (157-408)

Antitoxin

• Cro/C1-type helix-turn-helix domain (18-65)

Sequences

Toxin

Protein

• Length: 450 a.a.
• Molecular weight: 49917.03 Da
• Isoelectric Point: 8.1879

>T191034 WP_204086889.1 NZ_CP069588:28916-30265 [Chromobacterium violaceum]
MGRRKQQQKLHVWMNGLPVGSWETGRAGDRLTYFDDWVAHPQGRPLSLSLPFLPGGMPHQGAAVAAFFDNLLPDSEAIRR
RLAQRHRLAETSPFQLLSALGRDCVGAIQLLPEDETPRDLRTIRGEALDEASIARLLRQAVAAEPLGLREDEADLRLSIA
GAQEKTALLRHAGRWLLPRDSTPTTHIFKLPLGLVGGMQADMRSSVENEWLCSRLVAGFGLPVAACQIARFEEQKVLVVE
RFDRRLSADGSWILRQPQEDMCQATATPPHLKYQADGGPGIARILDILDGSQARERDRMDFFRAQLVFWLLAATDGHAKN
FSLFHLPGGQYQATPLYDILSTHPIIGNGSGRIAPQKVKLAMAVRGRNNHYLLERIRYSHWLAQARQVGLAPGQTARWID
ELVEQTDAVVQTVAKELPADFPQDVADAIFQGMRRQRDKLAAGKLAGDE

Nucleotide

• Length: 1350 bp

>T191034 NZ_CP091622:3510233-3510478 [Salmonella enterica]
ATGAATGCCTCCGGCGTCAGCGTCCGCCACATCAACAGCGAAACCTGCATGACCGCCTGTTACTCACAAATCCCCAGCGG
CGACTGCCAGGAAGAAGCGGGATTTGAGACCGGGCGCAGCGTGACGGTGAAGATTTCGGACGGGTGTATTGTGCTAATGG
CGGACGGTAACGAGGTGCAGAAGCTGTGCGAACAGCTTTATCAGGCTGAACAGGTAGTTAAGGGGATGTGGGACGTGATT
GTTTAG

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9334.63 Da
• Isoelectric Point: 8.5556

>AT191034 WP_048404587.1 NZ_CP069588:28651-28914 [Chromobacterium violaceum]
MQYPVRTLEQLRPLLLGLRKAAGLTQTQLAARLGVSQQSYARLEANPAAASVERLYRALRALDAELALSSPGSPPPPSAA
DAHGEEW

Nucleotide

• Length: 264 bp

>AT191034 NZ_CP091622:c3510442-3510086 [Salmonella enterica]
TTCAGCCTGATAAAGCTGTTCGCACAGCTTCTGCACCTCGTTACCGTCCGCCATTAGCACAATACACCCGTCCGAAATCT
TCACCGTCACGCTGCGCCCGGTCTCAAATCCCGCTTCTTCCTGGCAGTCGCCGCTGGGGATTTGTGAGTAACAGGCGGTC
ATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTC
CGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTGAGCGAGTATGGGCGCGACATCCTGGCATCGCGCCTCTCTCTCCCCG
GCCAGTGATGAGCAACCGGCTGCCGGGGCCGTATTTT