191021

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4435707..4436302 Replicon chromosome
Accession NZ_CP069583
Organism Escherichia coli strain FDAARGOS_1265

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag I6J95_RS21835 Protein ID WP_000239579.1
Coordinates 4435707..4436057 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag I6J95_RS21840 Protein ID WP_001223208.1
Coordinates 4436051..4436302 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6J95_RS21815 4431153..4432175 - 1023 WP_001296689.1 ABC transporter permease -
I6J95_RS21820 4432189..4433691 - 1503 WP_000205813.1 sugar ABC transporter ATP-binding protein -
I6J95_RS21825 4433831..4434787 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
I6J95_RS21830 4435097..4435627 + 531 WP_000055075.1 inorganic diphosphatase -
I6J95_RS21835 4435707..4436057 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
I6J95_RS21840 4436051..4436302 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
I6J95_RS21845 4436514..4436855 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
I6J95_RS21850 4436858..4440637 - 3780 WP_000060945.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T191021 WP_000239579.1 NZ_CP069583:c4436057-4435707 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T191021 NZ_CP091619:1968024-1968127 [Salmonella enterica]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT191021 WP_001223208.1 NZ_CP069583:c4436302-4436051 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT191021 NZ_CP091619:c1968129-1967986 [Salmonella enterica]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References