Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4338655..4339490 Replicon chromosome
Accession NZ_CP069583
Organism Escherichia coli strain FDAARGOS_1265

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0J2AEA6
Locus tag I6J95_RS21355 Protein ID WP_000854759.1
Coordinates 4338655..4339032 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1NM52
Locus tag I6J95_RS21360 Protein ID WP_001295723.1
Coordinates 4339122..4339490 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6J95_RS21325 4334593..4334769 - 177 Protein_4184 helix-turn-helix domain-containing protein -
I6J95_RS21330 4334961..4335707 - 747 WP_001016257.1 IS21-like element ISEc12 family helper ATPase IstB -
I6J95_RS21335 4335722..4337263 - 1542 WP_001298859.1 IS21-like element ISEc12 family transposase -
I6J95_RS21340 4337719..4337877 - 159 WP_001467148.1 hypothetical protein -
I6J95_RS21345 4337977..4338153 - 177 WP_000839286.1 DUF957 domain-containing protein -
I6J95_RS21350 4338170..4338658 - 489 WP_000761690.1 hypothetical protein -
I6J95_RS21355 4338655..4339032 - 378 WP_000854759.1 TA system toxin CbtA family protein Toxin
I6J95_RS21360 4339122..4339490 - 369 WP_001295723.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
I6J95_RS21365 4339653..4339874 - 222 WP_000692345.1 DUF987 domain-containing protein -
I6J95_RS21370 4339937..4340413 - 477 WP_001186775.1 RadC family protein -
I6J95_RS21375 4340429..4340902 - 474 WP_001350782.1 antirestriction protein -
I6J95_RS21380 4341244..4342062 - 819 WP_001234738.1 DUF945 domain-containing protein -
I6J95_RS21385 4342217..4342375 - 159 WP_001323397.1 DUF905 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14144.26 Da        Isoelectric Point: 7.3249

>T191020 WP_000854759.1 NZ_CP069583:c4339032-4338655 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDLPGF
SACTHSQLINSIDILRARRATGLMIRDNYRTVNNITLGKHPEAKR

Download         Length: 378 bp

>T191020 NZ_CP091619:c1009404-1008877 [Salmonella enterica]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGAAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGGGATACGATGTGCCAGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGTGGCGTAGCCCTGCTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTACTG
TCGTTTAAAACGCTTTATGCGGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13592.40 Da        Isoelectric Point: 6.6255

>AT191020 WP_001295723.1 NZ_CP069583:c4339490-4339122 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT191020 NZ_CP091619:c1009691-1009401 [Salmonella enterica]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGGCTGTCGTTGCGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACGTACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGCGATACTCAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCCGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J2AEA6

Antitoxin

Source ID Structure
AlphaFold DB S1NM52

References