Detailed information of TA system TA191019

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 4303447..4304267
• Replicon: chromosome
• Accession: NZ_CP069583
• Organism: Escherichia coli strain FDAARGOS_1265

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: B6I030
• Locus tag: I6J95_RS21180
• Protein ID: WP_001054379.1
• Coordinates: 4303447..4303704 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: I6J95_RS21185
• Protein ID: WP_000123957.1
• Coordinates: 4303716..4304267 (+)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6J95_RS21160	4298994..4299974	+	981	WP_000991462.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-
I6J95_RS21165	4300557..4301663	-	1107	Protein_4152	DNA helicase	-
I6J95_RS21170	4301726..4302873	+	1148	WP_085949154.1	IS3-like element ISEc52 family transposase	-
I6J95_RS21175	4302906..4303070	+	165	Protein_4154	GNAT family N-acetyltransferase	-
I6J95_RS21180	4303447..4303704	+	258	WP_001054379.1	YjhX family toxin	Toxin
I6J95_RS21185	4303716..4304267	+	552	WP_000123957.1	N-acetyltransferase	Antitoxin
I6J95_RS21190	4304319..4305065	+	747	WP_000354249.1	class I SAM-dependent methyltransferase	-
I6J95_RS21195	4305193..4305453	+	261	WP_000077645.1	hypothetical protein	-
I6J95_RS21200	4305491..4305607	+	117	Protein_4159	VOC family protein	-
I6J95_RS21205	4305852..4306973	+	1122	WP_112032097.1	M42 family metallopeptidase	-
I6J95_RS21210	4306970..4307248	+	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
I6J95_RS21215	4307260..4308573	+	1314	WP_000460845.1	galactitol-specific PTS transporter subunit IIC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fimE	4292068..4312488	20420

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (19-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9568.07 Da
• Isoelectric Point: 11.1381

>T191019 WP_001054379.1 NZ_CP069583:4303447-4303704 [Escherichia coli]
MNLSRQEQRTLHVLAKGGRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Nucleotide

• Length: 258 bp

>T191019 NZ_CP091619:843523-843936 [Salmonella enterica]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGTCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CGCGCCAACACTGA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20358.34 Da
• Isoelectric Point: 6.4182

>AT191019 WP_000123957.1 NZ_CP069583:4303716-4304267 [Escherichia coli]
MTAHHFTFQITDESDASDIREVETRAFGFSKEADLTASLLEDESARPALSLLARHEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQALTA
QPMNVTGHIQCAQALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT191019 NZ_CP091619:843276-843542 [Salmonella enterica]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Toxin

• AlphaFold DB: B6I030