Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 4143247..4143767 Replicon chromosome
Accession NZ_CP069583
Organism Escherichia coli strain FDAARGOS_1265

Toxin (Protein)


Gene name ccdB Uniprot ID A0A061KX66
Locus tag I6J95_RS20410 Protein ID WP_001160964.1
Coordinates 4143247..4143531 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID V0VEX8
Locus tag I6J95_RS20415 Protein ID WP_000125566.1
Coordinates 4143534..4143767 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6J95_RS20385 4138892..4140178 + 1287 WP_000800457.1 peptidylprolyl isomerase SurA -
I6J95_RS20390 4140178..4141167 + 990 WP_000241227.1 4-hydroxythreonine-4-phosphate dehydrogenase PdxA -
I6J95_RS20395 4141164..4141985 + 822 WP_001065365.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
I6J95_RS20400 4141988..4142365 + 378 WP_000610901.1 Co2+/Mg2+ efflux protein ApaG -
I6J95_RS20405 4142372..4143220 + 849 WP_000257181.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) ApaH -
I6J95_RS20410 4143247..4143531 - 285 WP_001160964.1 CcdB family protein Toxin
I6J95_RS20415 4143534..4143767 - 234 WP_000125566.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
I6J95_RS20420 4143853..4144332 - 480 WP_000624375.1 type 3 dihydrofolate reductase -
I6J95_RS20425 4144524..4146386 - 1863 WP_000377106.1 glutathione-regulated potassium-efflux system protein KefC -
I6J95_RS20430 4146379..4146909 - 531 WP_000600725.1 glutathione-regulated potassium-efflux system oxidoreductase KefF -
I6J95_RS20435 4147017..4148348 - 1332 WP_001183209.1 MFS transporter -
I6J95_RS20440 4148407..4148694 - 288 WP_000203744.1 ferredoxin-like protein FixX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-93)

Antitoxin

Post-segregation antitoxin CcdA

(8-77)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10692.54 Da        Isoelectric Point: 10.3030

>T191017 WP_001160964.1 NZ_CP069583:c4143531-4143247 [Escherichia coli]
MQFTVYRSRGRNAAFPFVIDVTSDIIGEINRRIVIPLTPIERFSRIRPPERLNPILLLIDGKEYVLMTHETATVPVNALG
TKFCDASAHRTLIK

Download         Length: 285 bp

>T191017 NZ_CP091619:213723-214208 [Salmonella enterica]
GTGGGACGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTAGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTCAACCATACAGAAGCGACAGGCAACCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGGAAAAGGGCTTGGGGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACATTGTTCCTTAGGCTCCCT
CAATAG

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8530.53 Da        Isoelectric Point: 5.8062

>AT191017 WP_000125566.1 NZ_CP069583:c4143767-4143534 [Escherichia coli]
MTAKRTTQSVTVTVDRELVNRARDAGLNMSATLTVALNAELKKHAATRWREENAEAIAALNQLADETGCFSDEYRSF

Download         Length: 234 bp

>AT191017 NZ_CP091619:213448-213735 [Salmonella enterica]
ATGCTATACAAAGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAATCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAACGGCCTGCCGGGCTGCCGAGAATGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGAGGAGTTCATTAATCTGCTTGATGCACCGGTCGCAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A061KX66

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LTM9

References