Detailed information of TA system TA191016

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 3874876..3876565
• Replicon: chromosome
• Accession: NZ_CP069583
• Organism: Escherichia coli strain FDAARGOS_1265

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A0A061KTE0
• Locus tag: I6J95_RS19120
• Protein ID: WP_000365807.1
• Coordinates: 3874876..3875796 (-)
• Length: 307 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: I6J95_RS19125
• Protein ID: WP_001295795.1
• Coordinates: 3875783..3876565 (-)
• Length: 261 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6J95_RS19080	3870349..3871059	+	711	WP_001295798.1	fimbrial chaperone EcpE	-
I6J95_RS19085	3871366..3871695	+	330	WP_001295797.1	YkgJ family cysteine cluster protein	-
I6J95_RS19090	3871707..3871870	-	164	Protein_3748	tail fiber assembly protein	-
I6J95_RS19095	3871944..3872558	-	615	WP_001019923.1	YagU family protein	-
I6J95_RS19100	3872773..3872958	-	186	WP_000146240.1	hypothetical protein	-
I6J95_RS19105	3873007..3873165	+	159	Protein_3751	integrase	-
I6J95_RS19110	3873392..3873727	+	336	WP_000996167.1	Arm DNA-binding domain-containing protein	-
I6J95_RS19115	3873935..3874711	+	777	WP_000171155.1	site-specific integrase	-
I6J95_RS19120	3874876..3875796	-	921	WP_000365807.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
I6J95_RS19125	3875783..3876565	-	783	WP_001295795.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
I6J95_RS19130	3876849..3879947	+	3099	WP_000673070.1	type I restriction endonuclease subunit R	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fdeC / ykgK/ecpR / yagZ/ecpA / yagY/ecpB / yagX/ecpC / yagW/ecpD / yagV/ecpE	3834660..3883628	48968

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-223)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (3-90)

Sequences

Toxin

Protein

• Length: 307 a.a.
• Molecular weight: 34570.89 Da
• Isoelectric Point: 7.3239

>T191016 WP_000365807.1 NZ_CP069583:c3875796-3874876 [Escherichia coli]
MDLRDSYARQVKLLMAALPHVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLAAINDALKRITASLNGR
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMPVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLGRPGLTREIFDGFLCYLAGHPRPIAELLASNWDTDRIATLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHFTDLDREFLLSFKQNSPDWSRYRYPEIQHLPAIRWKQRNLAMLKDKNPAKYVAAVNKLERVLE

Nucleotide

• Length: 921 bp

>T191016 NZ_CP091617:c4800-4285 [Salmonella enterica]
ATGAAATTTTACACTATATCAAGCAGATACATTGAATACCTAAAGGGATTCGAAGACAAAGTTCCCAATAGCGAAGATCC
TAACTATCAGAATCCGAAAGCTTTCATTGGCATTGTGTTAGAGATTCAAGGGCATAAGTATCTAGCCCCTTTAACATCCC
CAAAGCCATGGCATAGCACTATTAAAGAATCATCGCCTAGCTTCTTTAAGCTCCATGAAAATGGTGTCCCCGAAAATCAG
CTCGGATTGATTAATCTGAAGTTCATGATTCCAATCATCGAAGCCGAAGTATCCTTACTTGACTTGAACGGTATGCCGAA
TACCGCCTACAAGAGAATGCTCTATAAGCAGCTCCAGTTTATTCGTGTAAATTCAGACAAAATAGCTGAGAAATCAGAGC
TTTTAAGGAAGCTCGTCCTGCAAGGAAAAATGCAAGGAACATGTAATTTTTCCCTGTTAGAAGAAAAATACCGAGATTTC
GGCAAAGAAGCTAATGACACGGAAGAAGGCGAGTAA

Antitoxin

Protein

• Length: 261 a.a.
• Molecular weight: 29099.24 Da
• Isoelectric Point: 8.5975

>AT191016 WP_001295795.1 NZ_CP069583:c3876565-3875783 [Escherichia coli]
MPNYLNWLMQNTLPGQVLLQSWLTRNGVDRKLSYLYVQNGWLRRIAHGVYCRTGREPDWVDAVYCLQTQWEKPVRVAGLT
SLALQGHAHYTEPGKPQVWLALPAYVKLPGWFAAFEQSATFITLYTSGLTVDVSSFTTELKIGDRQLAGSAPELAAYEIA
CGVPSLISFEHADALFQGGNLLSPRKLQALLRASHSIKTNRVMLYLARRNGHPYFQYLDQSGIETGTGKRQIIPGGWLEP
DYQITVPRTFKPEGVEDGSA

Nucleotide

• Length: 783 bp

>AT191016 NZ_CP091617:c5013-4802 [Salmonella enterica]
AGGTGATTTGCTACCTTTAAGTGCAGCTAGAAATTCAGGTGATTTGCTACCTTAAGTGCAGCTAGAAATTCAGGTGATTT
GCTACCTTTAAGTGCAGCTAGAAATTCAGGTGATTTGCTACCTTAAGTGCAGCTAGAAATTTAGGTCATTTACTACCTTA
AAGTAATACAGTAAAAGAGGCGACTACACAGTCGCCTTTTTTACGAGAAAAA

Structures

Toxin

• AlphaFold DB: A0A061KTE0