Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1842867..1843698 Replicon chromosome
Accession NZ_CP069583
Organism Escherichia coli strain FDAARGOS_1265

Toxin (Protein)


Gene name yeeV Uniprot ID A0A066T988
Locus tag I6J95_RS08705 Protein ID WP_000854815.1
Coordinates 1842867..1843241 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A061Y7A8
Locus tag I6J95_RS08710 Protein ID WP_001280918.1
Coordinates 1843330..1843698 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6J95_RS08665 1838263..1839429 + 1167 WP_001296209.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -
I6J95_RS08670 1839548..1840021 + 474 WP_001105368.1 DNA gyrase inhibitor SbmC -
I6J95_RS08675 1840219..1841277 + 1059 WP_001200889.1 FUSC family protein -
I6J95_RS08680 1841449..1841778 + 330 WP_000450409.1 DUF496 family protein -
I6J95_RS08685 1841879..1842061 - 183 WP_001296208.1 hypothetical protein -
I6J95_RS08690 1842115..1842261 + 147 Protein_1701 transposase domain-containing protein -
I6J95_RS08695 1842550..1842663 - 114 WP_001161660.1 DUF957 domain-containing protein -
I6J95_RS08700 1842676..1842870 - 195 WP_000988600.1 hypothetical protein -
I6J95_RS08705 1842867..1843241 - 375 WP_000854815.1 type IV toxin-antitoxin system toxin CbtA Toxin
I6J95_RS08710 1843330..1843698 - 369 WP_001280918.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
I6J95_RS08715 1843714..1844358 - 645 WP_000086752.1 hypothetical protein -
I6J95_RS08720 1844377..1844598 - 222 Protein_1707 DUF987 domain-containing protein -
I6J95_RS08725 1844661..1845137 - 477 WP_001186200.1 RadC family protein -
I6J95_RS08730 1845153..1845626 - 474 WP_001542276.1 antirestriction protein -
I6J95_RS08735 1845720..1845965 - 246 WP_001164966.1 hypothetical protein -
I6J95_RS08740 1845965..1846783 - 819 WP_001542275.1 DUF945 domain-containing protein -
I6J95_RS08745 1847004..1847414 - 411 WP_000846703.1 hypothetical protein -
I6J95_RS08750 1847430..1847780 - 351 Protein_1713 hypothetical protein -
I6J95_RS08755 1847863..1848609 - 747 WP_001016257.1 IS21-like element ISEc12 family helper ATPase IstB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13829.83 Da        Isoelectric Point: 7.1326

>T191005 WP_000854815.1 NZ_CP069583:c1843241-1842867 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTSDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T191005 NZ_CP091611:4489574-4489885 [Salmonella enterica]
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCCCTCACTGAGTTGCT
GAATGTTCTTGAGAAAAAAACATTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTGGATAATTTTAAGTACA
GAGATAAATGGTGGGTGATTGATGTTTCTGATAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATATTATCGGGGTAATAAAGAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13811.70 Da        Isoelectric Point: 6.4767

>AT191005 WP_001280918.1 NZ_CP069583:c1843698-1843330 [Escherichia coli]
VSDKLHETNYPDDHNDRLWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT191005 NZ_CP091611:4489882-4490328 [Salmonella enterica]
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAAGCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTTAAACTACCAGCGGATGCCTTCATCGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A066T988

Antitoxin

Source ID Structure
AlphaFold DB A0A061Y7A8

References