Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 709068..709902 | Replicon | chromosome |
| Accession | NZ_CP069583 | ||
| Organism | Escherichia coli strain FDAARGOS_1265 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | S1PLF5 |
| Locus tag | I6J95_RS03410 | Protein ID | WP_000854690.1 |
| Coordinates | 709068..709445 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | S1P7N8 |
| Locus tag | I6J95_RS03415 | Protein ID | WP_001305076.1 |
| Coordinates | 709534..709902 (-) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| I6J95_RS03380 | 705462..705617 | - | 156 | WP_000729638.1 | hypothetical protein | - |
| I6J95_RS03385 | 706049..706982 | - | 934 | Protein_664 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | - |
| I6J95_RS03390 | 706975..707370 | - | 396 | WP_000208384.1 | type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein | - |
| I6J95_RS03395 | 707439..708284 | - | 846 | WP_001529401.1 | DUF4942 domain-containing protein | - |
| I6J95_RS03400 | 708369..708566 | - | 198 | WP_000839293.1 | DUF957 domain-containing protein | - |
| I6J95_RS03405 | 708583..709071 | - | 489 | WP_000761699.1 | hypothetical protein | - |
| I6J95_RS03410 | 709068..709445 | - | 378 | WP_000854690.1 | TA system toxin CbtA family protein | Toxin |
| I6J95_RS03415 | 709534..709902 | - | 369 | WP_001305076.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| I6J95_RS03420 | 709952..710596 | - | 645 | WP_000094916.1 | hypothetical protein | - |
| I6J95_RS03425 | 710615..710836 | - | 222 | WP_000692329.1 | DUF987 domain-containing protein | - |
| I6J95_RS03430 | 710899..711375 | - | 477 | WP_001186726.1 | RadC family protein | - |
| I6J95_RS03435 | 711391..711876 | - | 486 | WP_000849565.1 | antirestriction protein | - |
| I6J95_RS03440 | 711931..712749 | - | 819 | WP_001234620.1 | DUF945 domain-containing protein | - |
| I6J95_RS03445 | 712850..713083 | - | 234 | WP_000902034.1 | DUF905 family protein | - |
| I6J95_RS03450 | 713162..713617 | - | 456 | WP_000581502.1 | hypothetical protein | - |
| I6J95_RS03455 | 713693..714820 | - | 1128 | Protein_678 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | kpsM / kpsT / kpsS / kpsC / kpsU / kpsD / kpsE / kpsF | 687451..711876 | 24425 | |
| - | flank | IS/Tn | - | - | 705462..705617 | 155 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14057.04 Da Isoelectric Point: 9.1510
>T191002 WP_000854690.1 NZ_CP069583:c709445-709068 [Escherichia coli]
MKTLPDTHVRAASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYAQVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR
MKTLPDTHVRAASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYAQVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR
Download Length: 378 bp
>T191002 NZ_CP091611:3533305-3533550 [Salmonella enterica]
ATGAATGCCTCCGGCGTCAGCGTCCGCCACATCAACAGCGAAACCTGCATGACCGCCTGTTACTCACAAATCCCCAGCGG
CGACTGCCAGGAAGAAGCGGGATTTGAGACCGGGCGCAGCGTGACGGTGAAGATTTCGGACGGGTGTATTGTGCTAATGG
CGGACGGTAACGAGGTGCAGAAGCTGTGCGAACAGCTTTATCAGGCTGAACAGGTAGTTAAGGGGATGTGGGACGTGATT
GTTTAG
ATGAATGCCTCCGGCGTCAGCGTCCGCCACATCAACAGCGAAACCTGCATGACCGCCTGTTACTCACAAATCCCCAGCGG
CGACTGCCAGGAAGAAGCGGGATTTGAGACCGGGCGCAGCGTGACGGTGAAGATTTCGGACGGGTGTATTGTGCTAATGG
CGGACGGTAACGAGGTGCAGAAGCTGTGCGAACAGCTTTATCAGGCTGAACAGGTAGTTAAGGGGATGTGGGACGTGATT
GTTTAG
Antitoxin
Download Length: 123 a.a. Molecular weight: 13560.39 Da Isoelectric Point: 4.7830
>AT191002 WP_001305076.1 NZ_CP069583:c709902-709534 [Escherichia coli]
MSDTLPGTTLPDDNKDLPWWGLPCTVTPCFGACLVQEGNRLHYLADRAGIRGRFSDADAYHPDQAFPLLMKQPELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCDYVYLAVYPTPEMKN
MSDTLPGTTLPDDNKDLPWWGLPCTVTPCFGACLVQEGNRLHYLADRAGIRGRFSDADAYHPDQAFPLLMKQPELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCDYVYLAVYPTPEMKN
Download Length: 369 bp
>AT191002 NZ_CP091611:c3533514-3533158 [Salmonella enterica]
TTCAGCCTGATAAAGCTGTTCGCACAGCTTCTGCACCTCGTTACCGTCCGCCATTAGCACAATACACCCGTCCGAAATCT
TCACCGTCACGCTGCGCCCGGTCTCAAATCCCGCTTCTTCCTGGCAGTCGCCGCTGGGGATTTGTGAGTAACAGGCGGTC
ATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTC
CGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTGAGCGAGTATGGGCGCGACATCCTGGCATCGCGCCTCTCTCTCCCCG
GCCAGTGATGAGCAACCGGCTGCCGGGGCCGTATTTT
TTCAGCCTGATAAAGCTGTTCGCACAGCTTCTGCACCTCGTTACCGTCCGCCATTAGCACAATACACCCGTCCGAAATCT
TCACCGTCACGCTGCGCCCGGTCTCAAATCCCGCTTCTTCCTGGCAGTCGCCGCTGGGGATTTGTGAGTAACAGGCGGTC
ATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTC
CGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTGAGCGAGTATGGGCGCGACATCCTGGCATCGCGCCTCTCTCTCCCCG
GCCAGTGATGAGCAACCGGCTGCCGGGGCCGTATTTT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|