Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2178899..2179413 Replicon chromosome
Accession NZ_CP069582
Organism Staphylococcus carnosus strain FDAARGOS_1204

Toxin (Protein)


Gene name mazF Uniprot ID A0A3G4R0E2
Locus tag I6J34_RS10865 Protein ID WP_075140914.1
Coordinates 2179063..2179413 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID B9DMI8
Locus tag I6J34_RS10860 Protein ID WP_015900820.1
Coordinates 2178899..2179066 (+) Length 56 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6J34_RS10835 2174805..2175275 + 471 WP_015900825.1 PH domain-containing protein -
I6J34_RS10840 2175268..2176755 + 1488 WP_103211911.1 PH domain-containing protein -
I6J34_RS10845 2176760..2177245 + 486 WP_053464712.1 PH domain-containing protein -
I6J34_RS10850 2177247..2177600 + 354 WP_015900822.1 holo-ACP synthase -
I6J34_RS10855 2177664..2178818 + 1155 WP_046100526.1 alanine racemase -
I6J34_RS10860 2178899..2179066 + 168 WP_015900820.1 hypothetical protein Antitoxin
I6J34_RS10865 2179063..2179413 + 351 WP_075140914.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
I6J34_RS10870 2179757..2180758 + 1002 WP_015900818.1 PP2C family protein-serine/threonine phosphatase -
I6J34_RS10875 2180834..2181160 + 327 WP_103211912.1 anti-sigma factor antagonist -
I6J34_RS10880 2181162..2181641 + 480 WP_015900816.1 anti-sigma B factor RsbW -
I6J34_RS10885 2181616..2182386 + 771 WP_015900815.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13075.18 Da        Isoelectric Point: 10.0708

>T190998 WP_075140914.1 NZ_CP069582:2179063-2179413 [Staphylococcus carnosus]
MMRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKSKYKLDKDSVILLEQIR
TVDKKRLKEKLTYLSDEKMKEIDNAIQISLGLTHRN

Download         Length: 351 bp

>T190998 NZ_CP091611:842746-843159 [Salmonella enterica]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGTCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CGCGCCAACACTGA

Antitoxin


Download         Length: 56 a.a.        Molecular weight: 6211.75 Da        Isoelectric Point: 3.6836

>AT190998 WP_015900820.1 NZ_CP069582:2178899-2179066 [Staphylococcus carnosus]
MSTFNQNRSYSLEQSLKEGYAQMADLNLSLATEAFSVECEACDCNESYLAFDKDE

Download         Length: 168 bp

>AT190998 NZ_CP091611:842499-842765 [Salmonella enterica]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G4R0E2

Antitoxin

Source ID Structure
AlphaFold DB A0A380F5Y4

References