190997

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2165539..2166050 Replicon chromosome
Accession NZ_CP069582
Organism Staphylococcus carnosus strain FDAARGOS_1204

Toxin (Protein)


Gene name TsdT Uniprot ID B9DMH5
Locus tag I6J34_RS10795 Protein ID WP_015900832.1
Coordinates 2165844..2166050 (+) Length 69 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID B9DMH6
Locus tag I6J34_RS10790 Protein ID WP_015900833.1
Coordinates 2165539..2165832 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6J34_RS10765 2160911..2161549 + 639 WP_046100516.1 thiamine phosphate synthase -
I6J34_RS10770 2161638..2162507 + 870 WP_015900837.1 membrane protein insertase YidC -
I6J34_RS10775 2162618..2163130 + 513 WP_046100517.1 GNAT family N-acetyltransferase -
I6J34_RS10780 2163221..2163868 - 648 WP_046100518.1 HD domain-containing protein -
I6J34_RS10785 2163893..2165374 - 1482 WP_046100519.1 cardiolipin synthase -
I6J34_RS10790 2165539..2165832 + 294 WP_015900833.1 copper-sensing transcriptional repressor CsoR Antitoxin
I6J34_RS10795 2165844..2166050 + 207 WP_015900832.1 cation transporter Toxin
I6J34_RS10800 2166065..2166274 + 210 WP_015900831.1 copper ion binding protein -
I6J34_RS10805 2166371..2168572 + 2202 WP_103211725.1 heavy metal translocating P-type ATPase -
I6J34_RS10810 2168648..2168788 + 141 WP_167313208.1 hypothetical protein -
I6J34_RS10815 2168860..2170077 - 1218 WP_015900829.1 rod shape-determining protein RodA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(27-65)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 69 a.a.        Molecular weight: 7833.72 Da        Isoelectric Point: 4.1353

>T190997 WP_015900832.1 NZ_CP069582:2165844-2166050 [Staphylococcus carnosus]
MQNSVIKIDGMETEEEQHKLHQHLIEMTGVSAVQVDMDSNEVRISYETPVNLNNLEKEIYDAGYQILN

Download         Length: 207 bp

>T190997 NZ_CP091611:317650-318003 [Salmonella enterica]
ATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGGCATGCCTGATCCTGG
GCGCGCGGAAGCGCTAATGTACCGGGTACTCAATCAAATCGAATATGAAGGGGTGACCGACGTGTGGCTGCTGGCGGCAA
TGCATTTGCTCGCTATATCCCGTGGGCATATCTTCAATGATGGTAACAAACGTACCGCCTTATTTATTACGCTGCTGTTT
TTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCGGATTTTGTCGATATGACAGTCGATGCGGCGGCAGGGCGGCTTAC
GCTGGAGCAAATTGTCGTTCGCTTACGCGCCTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11132.76 Da        Isoelectric Point: 6.4862

>AT190997 WP_015900833.1 NZ_CP069582:2165539-2165832 [Staphylococcus carnosus]
MTENDKAHHSEQIKSNLKARLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAVRLLDHHMKGCIMHKVEDGHA
EEAMEELLVTVQKLIKD

Download         Length: 294 bp

>AT190997 NZ_CP091611:317416-317637 [Salmonella enterica]
ATGCGTACGGTTAACTATAGCGAAGCGCGGCAAAATCTGGCCGAAGTCCTGGAAAGTGCGGTGACGGGGGGCCCTGTCAC
CATCACGCGTCGTGGGCATAAGTCCGCAGTGATCATCAGCGCCGAGGAGTTTGAGCGTTATCAGACGGCGCGAATGGATG
ATGAGTTTGCTGCCATTATGGCGGTTCATGGCAATGAGCTCAGGGAGCTGGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A380F432

Antitoxin

Source ID Structure
AlphaFold DB A0A380F6K8

References