Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4726239..4727074 Replicon chromosome
Accession NZ_CP069571
Organism Escherichia coli strain FDAARGOS_1250

Toxin (Protein)


Gene name yeeV Uniprot ID A0A7W4PV54
Locus tag I6J80_RS23535 Protein ID WP_000854821.1
Coordinates 4726239..4726616 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A1M0D404
Locus tag I6J80_RS23540 Protein ID WP_024214935.1
Coordinates 4726706..4727074 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6J80_RS23500 4721530..4721658 - 129 Protein_4479 aldo/keto reductase -
I6J80_RS23505 4721961..4722449 + 489 Protein_4480 helix-turn-helix domain-containing protein -
I6J80_RS23510 4722466..4723163 - 698 Protein_4481 IS1 family transposase -
I6J80_RS23515 4723475..4724794 + 1320 WP_000144688.1 site-specific integrase -
I6J80_RS23520 4724887..4725735 - 849 WP_001280470.1 DUF4942 domain-containing protein -
I6J80_RS23525 4725820..4726017 - 198 WP_089075429.1 DUF957 domain-containing protein -
I6J80_RS23530 4726045..4726242 - 198 Protein_4485 hypothetical protein -
I6J80_RS23535 4726239..4726616 - 378 WP_000854821.1 type IV toxin-antitoxin system toxin CbtA Toxin
I6J80_RS23540 4726706..4727074 - 369 WP_024214935.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
I6J80_RS23545 4727154..4727375 - 222 WP_000692350.1 DUF987 domain-containing protein -
I6J80_RS23550 4727462..4727938 - 477 WP_001186745.1 RadC family protein -
I6J80_RS23555 4727954..4728439 - 486 WP_204156951.1 antirestriction protein -
I6J80_RS23560 4728531..4729349 - 819 WP_204156952.1 DUF945 domain-containing protein -
I6J80_RS23565 4729439..4729672 - 234 WP_001117566.1 DUF905 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13930.95 Da        Isoelectric Point: 8.5163

>T190982 WP_000854821.1 NZ_CP069571:c4726616-4726239 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T190982 NZ_CP091604:c4038008-4037724 [Salmonella enterica]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGACGATACGGTGAAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCCGTTTAAACGGTCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGTCTGGTGTACCAGGTTCGGGATGAAGTTGTGATTGTGTTTGTTGTTGCGGTCGGCAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13605.41 Da        Isoelectric Point: 6.4659

>AT190982 WP_024214935.1 NZ_CP069571:c4727074-4726706 [Escherichia coli]
VSDTLPGTTLPDDNNDRTWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSNADSYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp

>AT190982 NZ_CP091604:c4038240-4037998 [Salmonella enterica]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACTCTTAGCGACA
GTGAAGATGCATTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7W4PV54

Antitoxin

Source ID Structure
AlphaFold DB A0A1M0D404

References