190981

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) itaRT/DUF1778(antitoxin)
Location 4595661..4596498 Replicon chromosome
Accession NZ_CP069571
Organism Escherichia coli strain FDAARGOS_1250

Toxin (Protein)


Gene name itaT Uniprot ID A0A140NB16
Locus tag I6J80_RS22905 Protein ID WP_000227786.1
Coordinates 4595956..4596498 (+) Length 181 a.a.

Antitoxin (Protein)


Gene name itaR Uniprot ID I2UQS9
Locus tag I6J80_RS22900 Protein ID WP_001297137.1
Coordinates 4595661..4595972 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6J80_RS22875 4590681..4591628 + 948 WP_001239440.1 cytochrome o ubiquinol oxidase subunit II -
I6J80_RS22880 4591650..4593641 + 1992 WP_000467180.1 cytochrome o ubiquinol oxidase subunit I -
I6J80_RS22885 4593631..4594245 + 615 WP_000179819.1 cytochrome o ubiquinol oxidase subunit III -
I6J80_RS22890 4594245..4594574 + 330 WP_000019869.1 cytochrome o ubiquinol oxidase subunit IV -
I6J80_RS22895 4594586..4595476 + 891 WP_000971336.1 heme o synthase -
I6J80_RS22900 4595661..4595972 + 312 WP_001297137.1 DUF1778 domain-containing protein Antitoxin
I6J80_RS22905 4595956..4596498 + 543 WP_000227786.1 GNAT family N-acetyltransferase Toxin
I6J80_RS22910 4596554..4597489 - 936 WP_001297127.1 sel1 repeat family protein -
I6J80_RS22915 4597906..4599270 + 1365 WP_001000978.1 MFS transporter -
I6J80_RS22920 4599398..4599889 - 492 WP_001138904.1 nucleotide binding protein YajQ -
I6J80_RS22925 4600057..4600968 + 912 WP_000705853.1 2-dehydropantoate 2-reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(68-156)

Antitoxin

Vibrio phage ICP1, Orf50

(14-97)


Sequences

Toxin        


Download         Length: 181 a.a.        Molecular weight: 19794.98 Da        Isoelectric Point: 8.3395

>T190981 WP_000227786.1 NZ_CP069571:4595956-4596498 [Escherichia coli]
MVDKHEEITLPIVLSCNYQSDITYPGQKQFDCGNPVIDKFVRASLKKSVRNSDCAAKALIDRQSGELIGICTFTAYSLEK
QRVSGVLQGSQPSEIGVVRLVMLGVARKYQKRGFGQDLLCDFFEHVKIIHQALPIKGVYLDADSAAINFYARLGFVQLSA
TPNAFGAVPMFLAIQHILAA

Download         Length: 543 bp

>T190981 NZ_CP091604:3535933-3536178 [Salmonella enterica]
ATGAATGCCTCCGGCGTCAGCGTCCGCCACATCAACAGCGAAACCTGCATGACCGCCTGTTACTCACAAATCCCCAGCGG
CGACTGCCAGGAAGAAGCGGGATTTGAGACCGGGCGCAGCGTGACGGTGAAGATTTCGGACGGGTGTATTGTGCTAATGG
CGGACGGTAACGAGGTGCAGAAGCTGTGCGAACAGCTTTATCAGGCTGAACAGGTAGTTAAGGGGATGTGGGACGTGATT
GTTTAG

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11358.04 Da        Isoelectric Point: 10.4825

>AT190981 WP_001297137.1 NZ_CP069571:4595661-4595972 [Escherichia coli]
MPGKTATLPDVDKTLKNARVELKTSPDAKNKLREAAQAVGVDLSAFILSAAMERAESVLDNQRRRELSNQSWELMNQLIA
EPAQPTLALKALMKRKNSDGRQA

Download         Length: 312 bp

>AT190981 NZ_CP091604:c3536142-3535786 [Salmonella enterica]
TTCAGCCTGATAAAGCTGTTCGCACAGCTTCTGCACCTCGTTACCGTCCGCCATTAGCACAATACACCCGTCCGAAATCT
TCACCGTCACGCTGCGCCCGGTCTCAAATCCCGCTTCTTCCTGGCAGTCGCCGCTGGGGATTTGTGAGTAACAGGCGGTC
ATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTC
CGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTGAGCGAGTATGGGCGCGACATCCTGGCATCGCGCCTCTCTCTCCCCG
GCCAGTGATGAGCAACCGGCTGCCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A140NB16

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0Y6B3

References