Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1928544..1929378 Replicon chromosome
Accession NZ_CP069571
Organism Escherichia coli strain FDAARGOS_1250

Toxin (Protein)


Gene name yeeV Uniprot ID A0A2T3TJB4
Locus tag I6J80_RS09755 Protein ID WP_000854811.1
Coordinates 1928544..1928921 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A2T3TJJ3
Locus tag I6J80_RS09760 Protein ID WP_001285590.1
Coordinates 1929010..1929378 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6J80_RS09735 1926342..1927562 + 1221 WP_000794251.1 capsular biosynthesis protein -
I6J80_RS09740 1927585..1927821 - 237 WP_000986719.1 hypothetical protein -
I6J80_RS09745 1927924..1928100 - 177 WP_000839288.1 DUF957 domain-containing protein -
I6J80_RS09750 1928117..1928547 - 431 Protein_1787 hypothetical protein -
I6J80_RS09755 1928544..1928921 - 378 WP_000854811.1 type IV toxin-antitoxin system toxin CbtA Toxin
I6J80_RS09760 1929010..1929378 - 369 WP_001285590.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
I6J80_RS09765 1929452..1929673 - 222 WP_000692300.1 DUF987 domain-containing protein -
I6J80_RS09770 1929742..1930218 - 477 WP_001186725.1 RadC family protein -
I6J80_RS09775 1930234..1930719 - 486 WP_000214310.1 antirestriction protein -
I6J80_RS09780 1930811..1931629 - 819 WP_001234593.1 DUF945 domain-containing protein -
I6J80_RS09785 1931784..1931918 - 135 WP_032144430.1 DUF905 family protein -
I6J80_RS09790 1932019..1932474 - 456 WP_000581502.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - ugd / kpsS 1906244..1943513 37269


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14041.14 Da        Isoelectric Point: 7.8839

>T190967 WP_000854811.1 NZ_CP069571:c1928921-1928544 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNIILGKHPEVKQ

Download         Length: 378 bp

>T190967 NZ_CP091601:c1742804-1742586 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13608.50 Da        Isoelectric Point: 6.6242

>AT190967 WP_001285590.1 NZ_CP069571:c1929378-1929010 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLYSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT190967 NZ_CP091601:c1743205-1742831 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2T3TJB4

Antitoxin

Source ID Structure
AlphaFold DB A0A2T3TJJ3

References