Detailed information of TA system TA190959

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PP_4151-4152/excise(antitoxin)
• Location: 26414..27414
• Replicon: plasmid unnamed
• Accession: NZ_CP069569
• Organism: Corynebacterium sp. FDAARGOS 1242 strain FDAARGOS_1242

Toxin (Protein)

• Gene name: PP_4152
• Uniprot ID: -
• Locus tag: I6J72_RS13050
• Protein ID: WP_086892511.1
• Coordinates: 26860..27414 (+)
• Length: 185 a.a.

Antitoxin (Protein)

• Gene name: PP_4151
• Uniprot ID: -
• Locus tag: I6J72_RS13045
• Protein ID: WP_086892529.1
• Coordinates: 26414..26863 (+)
• Length: 150 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6J72_RS13005	21712..22302	+	591	WP_023016433.1	hypothetical protein	-
I6J72_RS13010	22483..22746	+	264	WP_011117479.1	hypothetical protein	-
I6J72_RS13015	23608..24201	-	594	WP_011117489.1	recombinase family protein	-
I6J72_RS13020	24201..24458	-	258	WP_187401021.1	hypothetical protein	-
I6J72_RS13025	24644..25189	+	546	WP_034666346.1	TetR/AcrR family transcriptional regulator	-
I6J72_RS13030	25186..25545	+	360	WP_048733039.1	cation transporter	-
I6J72_RS13035	25542..25871	+	330	WP_003849969.1	multidrug efflux SMR transporter	-
I6J72_RS13040	25971..26285	+	315	WP_174232238.1	NIPSNAP family protein	-
I6J72_RS13045	26414..26863	+	450	WP_086892529.1	helix-turn-helix domain-containing protein	Antitoxin
I6J72_RS13050	26860..27414	+	555	WP_086892511.1	PIN domain-containing protein	Toxin
I6J72_RS13055	27552..27851	-	300	WP_201829656.1	transposase	-
I6J72_RS13060	27938..28135	+	198	WP_201829658.1	CPBP family intramembrane metalloprotease	-
I6J72_RS13065	28523..29119	+	597	WP_201829660.1	ParA family protein	-
I6J72_RS13070	29130..29366	+	237	WP_201829662.1	peptide transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	erm(X)	-	1..31022	31022

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (6-112)

Antitoxin

• Helix-turn-helix domain, group 17 (79-126)

Sequences

Toxin

Protein

• Length: 185 a.a.
• Molecular weight: 20528.32 Da
• Isoelectric Point: 4.3345

>T190959 WP_086892511.1 NZ_CP069569:26860-27414 [Corynebacterium sp. FDAARGOS 1242]
VSGFTVIYDANVLYPNMLRDILIRLAGTGIYQARWTEDILDEVFRNLQANRPDLDPSKLRRTRELMCRAVDDCLVTGYED
LIESLSLPDPDDRHVLAAAIRCGAQVIVTENARDFPQDVMDKYGIEIQGADEFLCDQIDLFGTRVHQAITYAAAAFKNPP
MTIDDVLDALARAGAPSAADLLRR

Nucleotide

• Length: 555 bp

>T190959 NZ_CP091595:68649-69008 [Acinetobacter baumannii]
ATGGCTTGGGATGTAGAAACAACAGAACTTTTTGATTCTTGGTTGGCAGAACAAGATGAAAATGCTCAAGATAAAATCTT
AGCGTCTTTGCTTGTTTTGTCAGAACTGGGGCCAAATCTAGGCCGGCCTCATGTTGATACTATTAAAGAATCAAAATATC
CGAACATGAAAGAGATACGTGTGCAAGTTAAAGGTCATCCGATCCGTGGTTTCTTTGCATTTGATCCAGAACGTAAAGCC
ATTGTTTTGTGTGCTGGAGATAAGAAAGGGCTAAATGAAAAAGCCTTTTATAAAGAAATGATCAAGATTGCAGATGAACA
ATATGAGCAATATTTACGTGATAATTACGGAGATAAATAA

Antitoxin

Protein

• Length: 150 a.a.
• Molecular weight: 16490.76 Da
• Isoelectric Point: 6.0987

>AT190959 WP_086892529.1 NZ_CP069569:26414-26863 [Corynebacterium sp. FDAARGOS 1242]
MAYLQDNEIASTAATAREALQKINRVLSDTSTNKDVKVVVEQSDEVIRLPREVATVLREILVNSVAGRSVSVIPMRAELT
TQQAANLLNVSRPHVIKLMDDGILPGHKVGTHRRIYAADVQAYKHQRDIEARTAADDLTALTEEMGLYE

Nucleotide

• Length: 450 bp

>AT190959 NZ_CP091595:69008-69307 [Acinetobacter baumannii]
ATGGCTAAATTAAACGATATAATTTCAAAACGCTCACCTGAAAGCCAACAACGCATCAAGAAAATGGCAAATCAAATGCT
ATTGGATATTAACCTATCGAACCTACGGGAAGAGTTAAAAATATCTCAAGCTGAAATTGCAAAAAATCTAGGTGTAAGCC
AAGCTGCTATTTCAAAACGTGAAAAATTAGGTAAAGATCTTAAGATTTCATCATTAAAAGAATATGTTGAAGCTATGGGT
GGCAAAGTAAGGTTAGATGTTGAGTTACCTAACGGAAAGCATGTTGCTATATCTATTTAA