190956

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 570862..571373 Replicon chromosome
Accession NZ_CP069567
Organism Staphylococcus condimenti strain FDAARGOS_1205

Toxin (Protein)


Gene name TsdT Uniprot ID A0A143PEZ9
Locus tag I6J35_RS02805 Protein ID WP_047132367.1
Coordinates 571167..571373 (+) Length 69 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID B9DMH6
Locus tag I6J35_RS02800 Protein ID WP_015900833.1
Coordinates 570862..571155 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6J35_RS02775 566229..566867 + 639 WP_047132363.1 thiamine phosphate synthase -
I6J35_RS02780 566956..567831 + 876 WP_047132364.1 membrane protein insertase YidC -
I6J35_RS02785 567942..568454 + 513 WP_047132365.1 GNAT family N-acetyltransferase -
I6J35_RS02790 568545..569192 - 648 WP_047132366.1 HD domain-containing protein -
I6J35_RS02795 569217..570697 - 1481 Protein_549 cardiolipin synthase -
I6J35_RS02800 570862..571155 + 294 WP_015900833.1 copper-sensing transcriptional repressor CsoR Antitoxin
I6J35_RS02805 571167..571373 + 207 WP_047132367.1 cation transporter Toxin
I6J35_RS02810 571388..571597 + 210 WP_047132368.1 copper ion binding protein -
I6J35_RS02815 571694..573895 + 2202 WP_047132369.1 heavy metal translocating P-type ATPase -
I6J35_RS02820 573971..574111 + 141 WP_165380001.1 hypothetical protein -
I6J35_RS02825 574191..575402 - 1212 WP_047132370.1 rod shape-determining protein RodA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(27-65)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 69 a.a.        Molecular weight: 7815.73 Da        Isoelectric Point: 4.1353

>T190956 WP_047132367.1 NZ_CP069567:571167-571373 [Staphylococcus condimenti]
MQNSVIKIDGMETEEEQHKLHQHLIEMTGVTAVQVDLDSNEIKISYETPVNLNNLEKEIYDAGYQILN

Download         Length: 207 bp

>T190956 NZ_CP091594:3021718-3021820 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11132.76 Da        Isoelectric Point: 6.4862

>AT190956 WP_015900833.1 NZ_CP069567:570862-571155 [Staphylococcus condimenti]
MTENDKAHHSEQIKSNLKARLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAVRLLDHHMKGCIMHKVEDGHA
EEAMEELLVTVQKLIKD

Download         Length: 294 bp

>AT190956 NZ_CP091594:c3021827-3021682 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A143PEZ9

Antitoxin

Source ID Structure
AlphaFold DB A0A380F6K8

References