Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1268516..1269030 Replicon chromosome
Accession NZ_CP069565
Organism Staphylococcus aureus strain FDAARGOS_1245

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag I6J75_RS06185 Protein ID WP_000581792.1
Coordinates 1268821..1269030 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag I6J75_RS06180 Protein ID WP_000138932.1
Coordinates 1268516..1268809 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6J75_RS06160 1263779..1264420 + 642 WP_000483153.1 thiamine phosphate synthase -
I6J75_RS06165 1264506..1265378 + 873 WP_000725802.1 membrane protein insertase YidC -
I6J75_RS06170 1266191..1266838 - 648 WP_001187629.1 HD domain-containing protein -
I6J75_RS06175 1266866..1268350 - 1485 WP_000571549.1 cardiolipin synthase -
I6J75_RS06180 1268516..1268809 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
I6J75_RS06185 1268821..1269030 + 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
I6J75_RS06190 1269158..1269295 + 138 WP_000828354.1 hypothetical protein -
I6J75_RS06195 1269559..1270761 - 1203 WP_001109939.1 rod shape-determining protein RodA -
I6J75_RS06200 1271079..1272149 + 1071 WP_000159631.1 D-alanine--D-alanine ligase -
I6J75_RS06205 1272164..1273522 + 1359 WP_000611462.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T190947 WP_000581792.1 NZ_CP069565:1268821-1269030 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T190947 NZ_CP091593:89304-89720 [Klebsiella pneumoniae]
GTGAACAAGACCTATATGCTCGACACCTGTATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTCCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGCCAGCGCATCGTTGTCTCGGCCATCACTTATTCTGAAATGCGCTTCGGGGCCACCGGCC
CGAAGGCCTCCCCGCGCCACGTCGAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGACGCCACCACGGAGATTAAGGTGGCGCTGCGAATGGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT190947 WP_000138932.1 NZ_CP069565:1268516-1268809 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT190947 NZ_CP091593:89077-89307 [Klebsiella pneumoniae]
ATGAGAACTGTATCCATTTTTAAAAACGGCAATAACCGCGCCATTCGTCTGCCCCGCGATCTGGATTTTGAGGGAGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATTATTTTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGTTCG
AGAAGGCAGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGATTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References