Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | sanaTA/AbiEii-DUF6088 |
| Location | 1243888..1245169 | Replicon | chromosome |
| Accession | NZ_CP069559 | ||
| Organism | Escherichia coli strain FDAARGOS_1259 | ||
Toxin (Protein)
| Gene name | sanaT | Uniprot ID | - |
| Locus tag | I6J89_RS05920 | Protein ID | WP_059342195.1 |
| Coordinates | 1243888..1244781 (-) | Length | 298 a.a. |
Antitoxin (Protein)
| Gene name | sanaA | Uniprot ID | V0YCI1 |
| Locus tag | I6J89_RS05925 | Protein ID | WP_000208383.1 |
| Coordinates | 1244774..1245169 (-) | Length | 132 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| I6J89_RS05900 | 1239038..1240021 | - | 984 | WP_001296394.1 | KpsF/GutQ family sugar-phosphate isomerase | - |
| I6J89_RS05905 | 1240647..1241402 | - | 756 | Protein_1140 | IS21-like element ISEc10 family helper ATPase IstB | - |
| I6J89_RS05910 | 1241399..1242898 | - | 1500 | WP_000174401.1 | IS21-like element ISEc10 family transposase | - |
| I6J89_RS05915 | 1243247..1243417 | - | 171 | Protein_1142 | IS110 family transposase | - |
| I6J89_RS05920 | 1243888..1244781 | - | 894 | WP_059342195.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
| I6J89_RS05925 | 1244774..1245169 | - | 396 | WP_000208383.1 | type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein | Antitoxin |
| I6J89_RS05930 | 1245238..1246083 | - | 846 | WP_023281696.1 | DUF4942 domain-containing protein | - |
| I6J89_RS05935 | 1246168..1246365 | - | 198 | WP_000839293.1 | DUF957 domain-containing protein | - |
| I6J89_RS05940 | 1246382..1246869 | - | 488 | Protein_1147 | hypothetical protein | - |
| I6J89_RS05945 | 1246866..1247243 | - | 378 | WP_000854689.1 | TA system toxin CbtA family protein | - |
| I6J89_RS05950 | 1247320..1247700 | - | 381 | WP_001285598.1 | type IV toxin-antitoxin system YeeU family antitoxin | - |
| I6J89_RS05955 | 1247750..1248394 | - | 645 | WP_000094916.1 | hypothetical protein | - |
| I6J89_RS05960 | 1248413..1248634 | - | 222 | WP_000692329.1 | DUF987 domain-containing protein | - |
| I6J89_RS05965 | 1248697..1249173 | - | 477 | WP_001186726.1 | RadC family protein | - |
| I6J89_RS05970 | 1249189..1249674 | - | 486 | WP_059342223.1 | antirestriction protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 298 a.a. Molecular weight: 34270.35 Da Isoelectric Point: 5.9850
>T190899 WP_059342195.1 NZ_CP069559:c1244781-1243888 [Escherichia coli]
MPELTSLFPDVADALDIESAAIVEKDYFVVDLLRLLKEIKPETHTLVFAGSTALSKAGISLNRMSEDIDIKLVPTENFMQ
NGRDKRRKIRKEIVQIITDVIHNSDIFSLDNENARITRDEYRYNEISVRYPQTFAQVPCLRPFIKLELMESTLLEHPESR
DIYSLVTELTGKGTPITAFPCATILSTQAEKLISMMRRTAAHLRNPEQQDDEFLVRHIYDNYCIVREKGVNVPVLKNFVQ
ICIQQDIERYGNQYPQFCSSPVDELKKGLDALRDYPVHKLRFQRFVNPMVFGNTQIN
MPELTSLFPDVADALDIESAAIVEKDYFVVDLLRLLKEIKPETHTLVFAGSTALSKAGISLNRMSEDIDIKLVPTENFMQ
NGRDKRRKIRKEIVQIITDVIHNSDIFSLDNENARITRDEYRYNEISVRYPQTFAQVPCLRPFIKLELMESTLLEHPESR
DIYSLVTELTGKGTPITAFPCATILSTQAEKLISMMRRTAAHLRNPEQQDDEFLVRHIYDNYCIVREKGVNVPVLKNFVQ
ICIQQDIERYGNQYPQFCSSPVDELKKGLDALRDYPVHKLRFQRFVNPMVFGNTQIN
Download Length: 894 bp
>T190899 NZ_CP091569:3498419-3498637 [Salmonella enterica]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA
Antitoxin
Download Length: 132 a.a. Molecular weight: 14608.03 Da Isoelectric Point: 11.3150
>AT190899 WP_000208383.1 NZ_CP069559:c1245169-1244774 [Escherichia coli]
MTTKDRIQSRLNRSKRYVFTRDDFRDIAGYDQVGRALRTLVNEGKLMKVGYGVYTKARRNIITGKIMPAAPGGSAAVITE
ALERLNIRYRLAGATECYNKGQSTQIPVSLGIKTPSRFKRVLIVGKSKINA
MTTKDRIQSRLNRSKRYVFTRDDFRDIAGYDQVGRALRTLVNEGKLMKVGYGVYTKARRNIITGKIMPAAPGGSAAVITE
ALERLNIRYRLAGATECYNKGQSTQIPVSLGIKTPSRFKRVLIVGKSKINA
Download Length: 396 bp
>AT190899 NZ_CP091569:3498017-3498391 [Salmonella enterica]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCCAATCCTGTTAGTTTGTCTTGTTAA
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCCAATCCTGTTAGTTTGTCTTGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|