Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 405197..406032 Replicon chromosome
Accession NZ_CP069559
Organism Escherichia coli strain FDAARGOS_1259

Toxin (Protein)


Gene name yeeV Uniprot ID A0A4S3WCD6
Locus tag I6J89_RS01905 Protein ID WP_021566610.1
Coordinates 405197..405574 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A2J4HRK6
Locus tag I6J89_RS01910 Protein ID WP_001354276.1
Coordinates 405664..406032 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6J89_RS01875 400572..401390 + 819 WP_000779409.1 lipoprotein NlpA -
I6J89_RS01880 401394..402317 - 924 WP_001445306.1 carboxylate/amino acid/amine transporter -
I6J89_RS01885 402484..402981 - 498 WP_000509810.1 hypothetical protein -
I6J89_RS01890 403573..404418 - 846 WP_021566612.1 DUF4942 domain-containing protein -
I6J89_RS01895 404503..404700 - 198 WP_000839269.1 DUF957 domain-containing protein -
I6J89_RS01900 404712..405200 - 489 WP_048237286.1 hypothetical protein -
I6J89_RS01905 405197..405574 - 378 WP_021566610.1 TA system toxin CbtA family protein Toxin
I6J89_RS01910 405664..406032 - 369 WP_001354276.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
I6J89_RS01915 406082..406726 - 645 Protein_355 antitoxin of toxin-antitoxin stability system -
I6J89_RS01920 406741..406962 - 222 WP_021566608.1 DUF987 domain-containing protein -
I6J89_RS01925 407031..407507 - 477 WP_001186742.1 RadC family protein -
I6J89_RS01930 407522..408007 - 486 WP_000214318.1 antirestriction protein -
I6J89_RS01935 408098..408916 - 819 WP_001234748.1 DUF945 domain-containing protein -
I6J89_RS01940 409007..409159 - 153 Protein_360 DUF905 family protein -
I6J89_RS01945 409194..410807 - 1614 WP_000080195.1 IS66-like element ISEc23 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14058.02 Da        Isoelectric Point: 7.8276

>T190896 WP_021566610.1 NZ_CP069559:c405574-405197 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T190896 NZ_CP091569:c1029512-1028985 [Salmonella enterica]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATACGATGTGCCGGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGTGGCGTAGCCCTACTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13649.47 Da        Isoelectric Point: 7.0261

>AT190896 WP_001354276.1 NZ_CP069559:c406032-405664 [Escherichia coli]
VSDTLSGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCKADTLSSCGYVYLAVYPTPKMKN

Download         Length: 369 bp

>AT190896 NZ_CP091569:c1029799-1029509 [Salmonella enterica]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGGCTGTCGTTACGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACATACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGCGATACTAAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCCGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4S3WCD6

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4HRK6

References