Detailed information of TA system TA190895

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): abiEi-abiEii/AbiEii(toxin)
• Location: 1495366..1496816
• Replicon: chromosome
• Accession: NZ_CP069558
• Organism: Streptococcus constellatus strain FDAARGOS_1208

Toxin (Protein)

• Gene name: abiEi
• Uniprot ID: F9P999
• Locus tag: I6J38_RS07425
• Protein ID: WP_006268819.1
• Coordinates: 1495962..1496816 (+)
• Length: 285 a.a.

Antitoxin (Protein)

• Gene name: abiEii
• Uniprot ID: A0A892RL19
• Locus tag: I6J38_RS07420
• Protein ID: WP_037592818.1
• Coordinates: 1495366..1495965 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6J38_RS07415	1494437..1495255	+	819	WP_022525747.1	hypothetical protein	-
I6J38_RS07420	1495366..1495965	+	600	WP_037592818.1	abortive infection protein	Antitoxin
I6J38_RS07425	1495962..1496816	+	855	WP_006268819.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
I6J38_RS07430	1496929..1498260	-	1332	WP_022525745.1	relaxase/mobilization nuclease domain-containing protein	-
I6J38_RS07435	1498266..1498616	-	351	WP_022525744.1	plasmid mobilization relaxosome protein MobC	-
I6J38_RS07440	1498982..1499158	+	177	WP_004633836.1	subtilosin A family bacteriocin	-
I6J38_RS07445	1499260..1500597	+	1338	WP_022525761.1	radical SAM protein	-
I6J38_RS07450	1500624..1500776	+	153	WP_004633833.1	hypothetical protein	-
I6J38_RS07455	1500773..1501483	+	711	WP_022525760.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1495366..1516200	20834

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (34-255)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 285 a.a.
• Molecular weight: 32648.54 Da
• Isoelectric Point: 4.6926

>T190895 WP_006268819.1 NZ_CP069558:1495962-1496816 [Streptococcus constellatus]
MKTSEQIKGAIRNISKKTGVNPNSLLQMCLFEGILEKLSKSKYSENFILKGGLLISSLIGVDMRSTMDMDTTIRGIPLNE
ESITKILNEILAIEIDADIEYKLIKLSPIRQEDVYEDFCASISCIFGKINAILNIDITTGDVITPREMNYSYSKILEEGT
IPIMTYTIETILAEKFETISSRNITTTRARDFYDLYMIYSIYKDKIDKDILRKAIERTSKYRGSFETALQYKEIVELFRE
SETPKELWKKYTQNNPYAKDVDFLDTISIYEEIGTVLNVNDDTK

Nucleotide

• Length: 855 bp

>T190895 NZ_CP091569:882492-882890 [Salmonella enterica]
ATGCTGAAATTCATGCTTGATACCAATACCTGTATTTTCACCATCAAAAATAAGCCCGAACACATCAGAGAACGCTTCAA
CCTCAATACATCCCGAATGTGTATCAGCTCCATCACCTTAATGGAGCTGATTTACGGTGCTGAAAAAAGCCTGGCGCCGG
AGCGTAATCTTGCCGTCGTGGAGGGATTTATCTCCCGCCTTGAGGTTTTGGATTACGATACACAGGCAGCGATACATACC
GGTCAAATCCGTGCCGAACTGGCCCGCAAGGGAACACCTGTCGGGCCTTATGACCAGATGATTGCTGGCCATGCCGGTAG
CCGCGGACTGGTCGTCGTCACAAACAATCTCCGCGAATTTGAACGCATTCCGGGTATCCGAATCGAAGACTGGTGCTAA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 23087.99 Da
• Isoelectric Point: 9.6364

>AT190895 WP_037592818.1 NZ_CP069558:1495366-1495965 [Streptococcus constellatus]
MSKRELLLKKIKENNGIITTKEALNLGIHKDILKELTIKEELEKIANGLYVLPDENIDEYLYFSYRIPKGIFSHETAAYL
QGLSTRMPLVYVMTVKVGDNVSRVKSARDNIIFKYVKKDYYDIGKITITSPFGREISVYDKERTILDIIKDKDRIDAQVF
SEAIKSYFAGKEKDLLKLSKYAIKMNMEQALKRYTEVLL

Nucleotide

• Length: 600 bp

>AT190895 NZ_CP091569:882265-882492 [Salmonella enterica]
ATGCACACAACACTTTTTTTTAGTAACCGGACCCAGGCAGTCAGATTGCCTAAATCGATATCCTTTCCGGAGGATGTGAA
ACATGTCGAAATCATTGCGGTTGGCAGAAGCAGAATCATTACTCCAGTCGGAGAATCCTGGGACAGCTGGTTCGATGGCG
AAGGCGCCAGTACTGATTTTATGAGTACCAGAGAACAACCCGCAGTACAGGAACGGGAAGGATTTTGA

Structures

Toxin

• AlphaFold DB: F9P999