Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2773438..2773960 Replicon chromosome
Accession NZ_CP069549
Organism Escherichia coli strain FDAARGOS_1253

Toxin (Protein)


Gene name relE Uniprot ID V0VCV4
Locus tag I6J83_RS13305 Protein ID WP_001105537.1
Coordinates 2773438..2773728 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V0SC69
Locus tag I6J83_RS13310 Protein ID WP_000212715.1
Coordinates 2773718..2773960 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6J83_RS13290 2768628..2770283 + 1656 WP_001338059.1 alpha,alpha-phosphotrehalase -
I6J83_RS13295 2770677..2772815 + 2139 WP_000187799.1 anaerobic ribonucleoside-triphosphate reductase -
I6J83_RS13300 2772973..2773437 + 465 WP_001106233.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
I6J83_RS13305 2773438..2773728 - 291 WP_001105537.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6J83_RS13310 2773718..2773960 - 243 WP_000212715.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
I6J83_RS13315 2774152..2774538 - 387 WP_001232246.1 cytochrome b562 -
I6J83_RS13320 2774721..2776073 - 1353 WP_001162187.1 metalloprotease PmbA -
I6J83_RS13325 2776167..2776718 + 552 WP_000166276.1 ribosome-associated protein -
I6J83_RS13330 2776876..2778249 - 1374 WP_001219792.1 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-72)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11383.19 Da        Isoelectric Point: 9.8531

>T190884 WP_001105537.1 NZ_CP069549:c2773728-2773438 [Escherichia coli]
MNYELTFDPRALKEWQKLGVTVREQFKKKLEDALKRPRNPSAKLRDLPDCYKIKLRTQGYRLVYQVNDKELLVLVIAIGK
RENSAVYEDADKRLDE

Download         Length: 291 bp

>T190884 NZ_CP091566:2021927-2022214 [Salmonella enterica]
ATGCCGATGGAGTTTGAATGGGATGCGAACAAGGCTAAAAGCAACCTGAGGAAGCACGGTGTCCGTTTTGAGGATGCGGT
ACTGGTGTTTGACGATCCCCGACACCTGTCACGTCAGGAGCGTTATGAGAATGGAGAATATCGTTGGCAGACCCTCGGCC
TTGTTCATGGCATTGTGGTCATTCTGGTTGCTCATAGCGTTCGGTTCGAAAGTGGTTTTGAAGTTATCCGTATCATCAGC
GCCCGCAAGGCAGACAGAAAAGAGAGGAATCGTTATGAGCATGGTTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9125.56 Da        Isoelectric Point: 5.1369

>AT190884 WP_000212715.1 NZ_CP069549:c2773960-2773718 [Escherichia coli]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAENGRMPVKTLTVSDSEEALLRTVRERLANPQEAIKVRLDEL

Download         Length: 243 bp

>AT190884 NZ_CP091566:2022201-2022503 [Salmonella enterica]
ATGAGCATGGTTAAACATAAACGCGGCAACGCATCCGCGCTGAGTGCTCAGCATGAGGCTGAACTGAAGGCGCTGGCGAA
AAAATCAGATGATGAGATTGATTACAGCGACATTCCCGCTTCGGAGGATGGGCAGTGGTCTGAAGCAGTGCGTGGTAAGT
TTTTTCGCCCGTTAAAAACTCAGGCCTCGGTGCGTATTGACGCCGATGTGATGGAGTGGCTGAAACGGCCAGGAAAAGGC
TACCAGACGCGGCTCAATGCCATTCTGCGCGAGGCGATGCTGCGCGAGCAAAATAAGAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0VCV4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9H4B3

References